老年结肠癌患者预后影响因素分析  

Analysis on Prognosis Factors of Elderly Patients with Colon Cancer

作　　者：李晓霞[1] 唐元新[1] 

机构地区：[1]中国医科大学附属第四医院胃肠外科,辽宁沈阳110032

出　　处：《中国普外基础与临床杂志》2011年第7期732-736,共5页Chinese Journal of Bases and Clinics In General Surgery

基　　金：辽宁省教育厅高等学校科研项目(项目编号:2008781);辽宁省自然科学基金资助项目(项目编号:20062053)~~

摘　　要：目的探讨老年结肠癌患者临床病理特点及预后的影响因素。方法回顾性分析405例≥60岁老年结肠癌患者(老年组)的临床资料,进行预后分析并与同期收治的146例≤40岁的结肠癌患者(青年组)的临床资料进行对比。结果 2组患者在家族肿瘤史、合并疾病、术前肠梗阻及肿瘤分化程度方面的差异均有统计学(P<0.05),老年组和青年组患者术后5年生存率分别为64.9%和56.8%(P<0.05)。多因素回归分析表明,合并其他疾病、术前血清CEA值、术前肠梗阻、肿瘤大体类型、淋巴结转移、肝转移及TNM分期是影响老年结肠癌患者术后生存的独立因素。结论 老年结肠癌有着独特的临床病理特点,预后较好。影响老年结肠癌患者术后生存的独立因素是合并其他疾病、术前血清CEA水平、并发肠梗阻、肿瘤大体类型、淋巴结转移、肝转移及TNM分期。Objective To investigate the clinicopathological characteristics and prognosis of elderly patients with colon cancer.Methods The clinicopathological and follow-up data of patients with colon cancer were compared retrospectively between those older than 60 years（405 patients） and those younger than 40 years（146 patients）.Results Family history,comorbidities,preoperative intestinal obstruction,and differentiation grade were significantly different between two groups（P〈0.05）.The 5-year survival rate of patients in elder group and younger group was 64.9% and 56.8% respectively,and there was significant difference（P〈0.05）.The multivariate analysis indicated that the independent predictors of survival were comorbidities,perioperative CEA level,preoperative intestinal obstruction,tumor gross type,lymph node metastasis,hepatic metastasis,and TNM stage.Conclusion Patients older than 60 years with colon cancer have unique clinicopathological characteristics and better prognosis.The independent predictors of survival are comorbidities,perioperative CEA level,preoperative intestinal obstruction,tumor gross type,lymph node metastasis,hepatic metastasis,and TNM stage.

关 键 词：结肠肿瘤 老年 预后 多因素分析 

分 类 号：R735.35[医药卫生—肿瘤]