老年期痴呆患者血清中钙镁锌铝含量的研究  

A Study on Serum Ca, Mg, Zn, Al Contents in Senile Dementia

作　　者：程吟梅[1] 葛炜[1] 张曙云[1] 朱建中[1] 何田美[1] 叶善龙 

机构地区：[1]解放军杭州疗养院,浙江杭州310007 [2]上海市长宁区老年痴呆专科医院,上海201103

出　　处：《科技通报》1999年第6期467-469,共3页Bulletin of Science and Technology

摘　　要：用等离子体直读光谱仪测定了５３ 例Ａｌｚｈｅｉｍ ｅｒ 型老年痴呆（ＳＤＡＴ）和２５ 例梗塞性痴呆（ＭＩＤ）患者血清中钙、镁、锌、铝的含量并以４９ 例同龄的健康老人作为对照，结果显示：ＳＤＡＴ组和ＭＩＤ组血清中钙、锌、铝含量均低于对照组（Ｐ＜ ０．０１），而镁在患者组和对照组间无差异，ＳＤＡＴ组与ＭＩＤ组间各元素均无差异．提示这些元素在酶与受体功能调节中起着关键的作用，它们的减少可能是损害中枢神经系统调节功能的原因之一。In order to explore the relationship between trace element and senile dementia, the contents of Ca, Mg, Zn, Al were detected in the serum of 53 senile dementia of Alzheimer type (SDAT), 25 multi infarct dementia (MID) and 49 aged healthy subjects as control. The result showed that the content of Ca, Zn, Al in SDAT and MID groups was lower than that in control ( P <0.01). There was no statistic significance of Mg element content between patients and control groups. No difference was observed for each element between SDAT and MID groups, suggesting that these elements played an important role in enzyme and receptor function regulation. The decreased trace element content might be one of causes that injured the regulation function of central nerve system and was related to the pathogenesis of senile dementia.

关 键 词：ALZHEIMER型 老年痴呆 梗塞性痴呆 血清 微量无 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R446.113[医药卫生—临床医学]