Probing cytotoxicity of CdSe and CdSe/CdS quantum dots  

作　　者：Yan Jie Bao Jun Jun Li Yi Ting Wang Lei Yu Lei Lou Wei Ji Du Zi Qiang Zhu Hui Peng Jian Zhong Zhu 

机构地区：[1]Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai 200062, China

出　　处：《Chinese Chemical Letters》2011年第7期843-846,共4页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation of China(No.60976004);Shanghai Municipal Commission for Science and Technology(No.09JC1405300)

摘　　要：Toxicities of CdSe and CdSe/CdS quantum dots （QDs） synthesized by ultrasound-assisted methods were investigated in vitro and in vivo. Five human cell lines were used to assess the cytotoxicity of as-prepared CdSe and CdSe/CdS by assays of MTT viability, red blood cell hemolysis, flow cytometry, and fluorescence imaging. The results show that these QDs may be cytotoxic by their influence in S and G2 phases in cell cycles. The cytotoxicity of QDs depends on both the physicochemical properties and related to target cells.Toxicities of CdSe and CdSe/CdS quantum dots （QDs） synthesized by ultrasound-assisted methods were investigated in vitro and in vivo. Five human cell lines were used to assess the cytotoxicity of as-prepared CdSe and CdSe/CdS by assays of MTT viability, red blood cell hemolysis, flow cytometry, and fluorescence imaging. The results show that these QDs may be cytotoxic by their influence in S and G2 phases in cell cycles. The cytotoxicity of QDs depends on both the physicochemical properties and related to target cells.

关 键 词：CYTOTOXICITY Quantum dots CDSE CdSe/CdS CELL 

分 类 号：Q959.133[生物学—动物学] TN304.25[电子电信—物理电子学]