A Practical Method to Stereospecifically Synthesize trans-Stilbene Derivatives  

作　　者：见玉娟 孙高军 李家明 苏丹 李传润 钟国琛 

机构地区：[1]Department of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230031, China [2]School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China [3]Department of Pharmacy, the Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui 230001, China

出　　处：《Chinese Journal of Chemistry》2011年第7期1423-1428,共6页中国化学（英文版）

摘　　要：A practical method to stereospecifically synthesize trans-stilbenes was developed via the one-pot benzylation-dehydration reaction of aromatic aldehydes with benzyltrimethylsilane （BTMS）, which was driven by tetrabu- tylammonium fluoride （TBAF） in THF. At the same time a plausible description of the whole process was proposed and the effects of substituted groups on the reaction were investigated. Also this method was employed to synthesize three precursors of natural products with excellent yields, which demonstrated that this method is much efficient and practical in the synthesis of some natural products.A practical method to stereospecifically synthesize trans-stilbenes was developed via the one-pot benzylation-dehydration reaction of aromatic aldehydes with benzyltrimethylsilane （BTMS）, which was driven by tetrabu- tylammonium fluoride （TBAF） in THF. At the same time a plausible description of the whole process was proposed and the effects of substituted groups on the reaction were investigated. Also this method was employed to synthesize three precursors of natural products with excellent yields, which demonstrated that this method is much efficient and practical in the synthesis of some natural products.

关 键 词：TRANS-STILBENE benzyltrimethylsilane aromatic aldehydes BENZYLATION natural products 

分 类 号：O625.12[理学—有机化学] O632.17[理学—化学]