Synthesis of Chiral 2-Aroyl-l-tetralols： Asymmetric Transfer Hydrgenation of 2-Aroyl-l-tetralones via Dynamic Kinetic Resolution  

作　　者：吴云 耿志聪 白进进 张雅文 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, China

出　　处：《Chinese Journal of Chemistry》2011年第7期1467-1472,共6页中国化学（英文版）

摘　　要：The dynamic kinetic resolution of 2-aroyl-l-tetralones was achieved via asymmetric transfer hydrogenation using （S,S）-RuCl（p-cymene）TsDPEN （TsDPEN=N-（tosyl）-1,2-diphenylethylenediamine） in formic acid/triethylamine （5 ： 2, molar ratio）, afforded the desired products in good yields （up to 85%） with diastereomeric ratio up to 〉99 ： 1 and high enantiomeric excesses （up to 〉99%）. The absolute configuration of major the product was con- firmed by X-ray crystal structure analysis.The dynamic kinetic resolution of 2-aroyl-l-tetralones was achieved via asymmetric transfer hydrogenation using （S,S）-RuCl（p-cymene）TsDPEN （TsDPEN=N-（tosyl）-1,2-diphenylethylenediamine） in formic acid/triethylamine （5 ： 2, molar ratio）, afforded the desired products in good yields （up to 85%） with diastereomeric ratio up to 〉99 ： 1 and high enantiomeric excesses （up to 〉99%）. The absolute configuration of major the product was con- firmed by X-ray crystal structure analysis.

关 键 词：dynamic kinetic resolution asymmetric transfer hydrogenation 2-aroyl-1-tetralones ENANTIOSELECTIVITY CHIRAL 

分 类 号：O621.34[理学—有机化学] O623.543[理学—化学]