Caveolin-1在前列腺癌中的表达及临床意义  

clinical significance of Caveolin-1 expression in patients with prostate cancerurinary surgery department

作　　者：卢桂尧[1] 杨永强[1] 范小明[1] 

机构地区：[1]广东医学院附属三水医院泌尿外科,528100

出　　处：《中国实用医药》2011年第20期35-37,共3页China Practical Medicine

摘　　要：目的探讨Caveolin-1的表达情况及其与前列腺癌的临床预后的关系。方法用EnVision免疫组织化学分析50例前列腺癌组织的表达情况以及与临床病理资料的相关性。结果 Caveolin-1在前列腺癌组织中高表达,阳性率为70%,而且高表达的前列腺癌患者预后差(P=0.028)。结论 Caveolin-1在前列腺癌组织中高表达可以作为临床预后差的分子标记物。Objective Discuss the relationship between the expression of Caveolin-1 in the prostate tissue and the clinic prognosis of prostatic cancer.Methods Analyzed the correlation between 50 cases of the expression of Caveolin-1 in the prostate cancer tissue with EnVision immunohistochemistry and clinic pathology.Results Caveolin-1 in the prostate cancer tissue was high,positive rate was 70%,and patients with prostatic cancer which Caveolin-1 was highly expressed and had poor prognosis（P=0.028）.Conclusion The high expression of Caveolin-1 in the prostate cancer tissue can be a molecular marker of poor clinic prognosis.

关 键 词：CAVEOLIN-1 免疫组织化学 前列腺癌 临床预后 

分 类 号：R737.25[医药卫生—肿瘤]