大肠癌CXCR4表达及其与预后的关系  

Expression of CXCR4 and its Relationship with Prognosis of Colorectal Cancer

作　　者：李权[1] 杨银龙[1] 张筱骅[1] 杨开颜[1] 万丽[1] 

机构地区：[1]温州医学院附属第一医院,浙江温州325000

出　　处：《肿瘤学杂志》2011年第6期454-456,共3页Journal of Chinese Oncology

摘　　要：[目的]探讨CXCR4在大肠癌中的表达情况及其与预后的关系。[方法]采用SP免疫组化方法检测70例大肠癌组织和14例癌旁组织中CXCR4蛋白的表达。[结果]CXCR4蛋白在大肠癌组织中阳性表达率为57.1%(40/70),显著高于癌旁组织的14.3%(2/14)(P<0.01)。CXCR4阳性表达与大肠癌的Duke分期(P=0.041)、淋巴结转移(P=0.018)显著相关。CXCR4阴性表达者的无瘤生存率显著优于阳性表达者(P=0.008)。[结论]CXCR4蛋白在大肠癌中过度表达与大肠癌的发生发展和预后相关。[Purpose] To investigate expression of CXCR4 and its relationship with prognosis of colorectal cancer. [Methods] The expression of CXCR4 in 70 cases with colorectal cancer tissue and 14 cases with cancer adjacent tissue was detected by immunohistochemistry. [Results] The positive rate of CXCR4 in colorectal cancer （57.1%,40/70） was significantly higher than that in cancer adjacent tissue （14.3%,2/14）（P〈0.01 ）.The positive expression of CXCR4 was related to Dukes＇ stage（P=0.041） and lymph node metastasis（P=0.018）. The disease free survival rate in CXCR4 positive expression group was significantly better than that in negative expression group （P= 0.008）. [Conclusion ] CXCR4 is over expression in colorectal cancer, and it relate to carcinogenesis and prognosis of colorectal cancer.

关 键 词：大肠肿瘤 CXCR4 免疫组化 预后 

分 类 号：R735.34[医药卫生—肿瘤]