血瘀证及活血药对肿瘤转移影响的相关分子机制研究概况  

An Overview on Molecular Mechanism of Blood Stasis Syndrome and Blood Activating Drug on Tumor Metastasis

作　　者：任为民[1] 张培彤[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国肿瘤》2011年第7期509-514,共6页China Cancer

基　　金：国家自然科学基金项目(30873334)

摘　　要：转移是恶性肿瘤治疗失败的重要原因之一。血瘀证与肿瘤转移有着一定的相关性,目前关于血瘀证和活血药对肿瘤转移的影响尚没有统一的结论。血瘀证与组织缺氧和缺氧诱导因子、血管内皮生长因子、细胞黏附分子表达的异常也有一定的联系,从上述分子水平明确血瘀证与肿瘤转移的关系、活血化瘀药物对肿瘤转移的影响,并对其作用机制进行深入研究,对丰富中医活血化瘀理论,寻找控制肿瘤转移的有效方法,指导肿瘤临床治疗具有重要意义。Metastasis is one of the main reasons of treatment failure of malignant tumor.There is a certain correlation between blood stasis syndrome and metastasis.At present,the effect of blood stasis syndrome and blood activating drug on tumor metastasis is still not a unified conclusion.The blood stasis syndrome relates to tissue anoxia,hypoxia-inducible factor,vascular endothelial growth factor（VEGF） and abnormal expression of cell adhesion molecules （CAMs）.By researching the relationship between blood stasis syndrome and tumor metastasis,the effect of blood activating drug on tumor metastasis,it has significant meanings of enriching the blood activating theory,finding an effective way of controlling tumor metastasis and guiding the clinical treatment.

关 键 词：肿瘤转移 血瘀证 活血药 

分 类 号：R73-37[医药卫生—肿瘤]