被动吸烟与乳腺癌相关性的荟萃分析  

Meta-analysis of the Relationship Between Passive Smoking and Breast Cancer

作　　者：马骏[1] 聂胜男[1] 史本玲[1] 左文述[1] 

机构地区：[1]山东省肿瘤医院山东省医学科学院,山东济南250117

出　　处：《中国肿瘤》2011年第7期525-528,共4页China Cancer

摘　　要：[目的]应用Meta分析探讨被动吸烟与乳腺癌的相关性。[方法]全面检索CHKD、CBM、VIP和Medline等中英文数据库,收集2001～2011年发表的被动吸烟与乳腺癌发病风险的相关文献。应用统计学软件对文献数据进行统计分析。[结果]共11项研究被纳入分析。11项研究存在异质性(Q=32.68,P=0.000),采用随机效应模型进行合并计算,合并RR值为1.23,合并95%CI为1.12～1.40。[结论]被动吸烟是乳腺癌的易感因素,通过各种方法减少被动吸烟,可以有效降低乳腺癌的发病风险。[Purpose] To explore the relationship between breast cancer and passive smoking.[Methods] A computer based search of CHKD,CBM,VIP and Medline databases was performed,and the literatures published from 2001 to 2011 were collected.The data of literatures was analyzed by statistics software.[Results] Totally 11 literatures were involved.Heterogeneity （except for threshold effect） was found within these studies（Q=32.68,P=0.000）.A Meta-analysis was performed using random effect model.Combined estimated of RR was 1.23 and its 95% CI was 1.12～1.40.[Conclusion] Passive smoking is probably a risk factor of breast cancer.Prevention of passive smoking could decrease the incidence of breast cancer.

关 键 词：乳腺癌 被动吸烟 烟草烟污染 META分析 

分 类 号：R737.9[医药卫生—肿瘤]