桑白皮生物碱与绿茶茶多酚的联合降糖作用  

Combined Effect of the Extracts from Cortex Mori Radicis and Green Tea on Diabetes

作　　者：耿鹏[1,2] 石倩[1] 杨洋[1] 白钢[1] 

机构地区：[1]南开大学生命科学学院,天津300071 [2]天津医药大学基础医学院,天津300070

出　　处：《南开大学学报（自然科学版）》2011年第3期76-79,共4页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：国家自然科学基金(30900015);天津市应用基础及前沿技术研究计划(11JCYBJC09300)

摘　　要：为研究桑白皮提取物(CME)与绿茶提取物(GTE)的联合降糖作用,提取桑白皮的生物碱成分与绿茶的茶多酚成分,分别在酶学水平、离体水平和体内水平评价CME与GTE单独或联合使用对α-葡萄糖苷酶活性的抑制效果.结果表明,CME与GTE在酶学水平的α-糖苷酶抑制实验和离体水平的反转肠囊实验中均显示出较强的α-糖苷酶抑制活性,且二者具有叠加作用.由二者组成的复方组分在体内水平的药理实验中也能有效降低糖尿病小鼠空腹血糖.因此,CME和GTE能够联合作用,通过抑制α-糖苷酶的活性,可以有效降低血糖.To investigate the combined effect of the extracts from Cortex Mori radicis （CME）and extracts from Green tea（GTE）on diabetes,the components of alkaloid and tea polyphenol were extracted respectively from Cortex Mori radicis and from Green tea,and the inhibition to the activity ofα-glucosidase of individual and combined extracts were detected on the level of enzymology,in vitro and in vivo.Compared with individual component,the combination of CME and GTE displayed stronger effects,in the inhibition toα-glucosidase activity and in everted rat intestinal sac system.Compared with control,the prescription combined of CME and GTE could remarkably depress the fasting blood glucose level in experimental-diabetic mice after a long-term treatment.Results indicated that combination of CME and GTE can inhibitα-glucosidase to effectively depress blood glucose level in the therapy to diabetes.

关 键 词：桑白皮 绿茶 复方 Α-糖苷酶抑制剂 糖尿病 

分 类 号：R96[医药卫生—药理学]