GHRP对心衰大鼠血清中IL-6含量的影响  

The effect of GHRP on the content of serum IL-6 in rats with heart failure

作　　者：赵勇[1] 田国忠[1] 郑衍芳[2] 李梅秀[1] 孙权[1] 欧叶涛[1] 

机构地区：[1]佳木斯大学基础医学院解剖学教研室 [2]遵义医学院珠海校区解剖学教研室

出　　处：《齐齐哈尔医学院学报》2011年第11期1709-1710,共2页Journal of Qiqihar Medical University

基　　金：黑龙江省卫生厅项目(2009-346);黑龙江省教育厅科研项目(11531386);佳木斯大学科学技术研究项目(S2009-071)

摘　　要：目的研究心衰大鼠血清中白细胞介素6(Interleukin-6,IL-6)的含量变化以及生长素释放肽(Growth hormone releasing peptide,GHRP)对其产生的干预作用。方法以阿霉素(Adriamy-cin,ADR)制备大鼠心衰模型,采用放射免疫学方法检测各组大鼠血清中IL-6的含量。结果模型组与正常组相比,左室峰压、左室压力最大上升和下降速率(±dp/dtmax)降低,而血清中IL-6含量增高,差异均有统计学意义(P<0.05);治疗组与模型组相比,左室峰压、±dp/dtmax增高,血清中IL-6含量降低,差异均有统计学意义(P<0.05)。结论 GHRP具有降低大鼠血清中IL-6含量和改善CHF大鼠心功能的作用。Objective To study the change of the content of serum IL-6 in rats with heart failure and the effect of GHRP on which. Methods Rat model of heart failure was prepared by injecting Adriamycin,and measure the content of IL-6 in serum of rats by Radioimmunoassay.Results Compared with normal group,the left ventricular peak pressure,left ventricular pressure maximal rising and falling rate of model group decreased,and the content of IL-6 of model group in serum increased.The differences were statistically significant.Compared with model group,the left ventricular peak pressure,left ventricular pressure maximal rising and falling rate of treatment group increased,and the content of IL-6 of treatment group in serum decreased.The differences between treatment group and model group were statistically significant.The differences between treatment group and normal group were not statistically significant.Conclusions The development of CHF is closely related to IL-6.GHRP can decrease the content of IL-6 in myocardium and improve heart function of rats with CHF.

关 键 词：生长素释放肽 慢性心力衰竭 白细胞介素6 

分 类 号：R575.2[医药卫生—消化系统]