广州市及周边地区胃肠癌发生的独立危险因素分析  

The independent risk factors for gastrointestinal cancer in Guangzhou and the surrounding areas

作　　者：吴雪莲[1] 魏宜胜[1] 容超贤[1] 贺意辉[1] 

机构地区：[1]广州医学院第二附属医院胃肠外科,510260

出　　处：《国际医药卫生导报》2011年第13期1554-1557,共4页International Medicine and Health Guidance News

摘　　要：目的探讨广州市及周边地区人群吸烟、饮酒、体重指数（bodv mass index，BMI）与胃肠癌的关系。方法纳入170例胃肠癌病例和166例健康人群，均来自广州及周边地区，年龄（±5岁）和性别相匹配。单因素卡方检验和多因素检验分析BMI、吸烟、饮酒与胃肠癌的关系。结果单因素卡方检验显示BMI、吸烟与胃肠癌无明显相关（P=0．46；P=0．88），饮酒与胃肠癌明显相关（P=0．03）。多因素回归分析显示与不饮酒者相比，曾经饮酒者明显增加胃肠癌的风险（OR1．89，95％CI=1．08—3．33，P=-0．03）。结论饮酒是广州市及周边地区人群胃肠癌发生的独立危险因素，应加强卫生宣教。Objective To investigate the association of the genesis of gastrointestinal cancer with tobacco smoking, alcohol intake, and body mass index （ BMI ） in Guangzhou and the surrounding areas. Methods 170 patients and 166 healthy controls from Guangzhou and the surrounding areas were included in this study. The patients and the controls were sex- and age- （ within 5 years ） matched. The association of gastrointestinal cancer with tobacco smoking, alcoholintake, and BMI were analyzed by single factor Chi-square test and Cox multivariate regression. Results Single factor Chi-square test showed BMI or tobacco smoking was not associated and the genesis of gastrointestinalcancer （P=0.46, P=-0.88）, while alcohol intake was associated with the genesis of gastrointestinal cancer （ P=-0.03 ）. Cox multivariate regression showed former drinkers, as compared nondrinkers, had an increased risk of gastrointestinal cancer （ adjusted OR 1.89, 95% CI = 1.08-3.33, P= 0.03 ）. Conclusions Alcohol intake is an independent risk factor for gastrointestinal cancer in Guangzhou and the surrounding areas. Health education should be strengthened.

关 键 词：胃癌 结直肠癌 饮酒 吸烟 BMI 

分 类 号：R735[医药卫生—肿瘤]