FHIT在乳腺癌中的表达及其与临床病理指标的关系  

Expression Character of FHIT in Breast Carcinomas and its Relationship with Clinicopathologial Parameters

作　　者：王富文[1] 徐国萍[2] 应学翔[1] 林燕苹[1] 何萍青[1] 

机构地区：[1]上海交通大学附属第六人民医院普外科,200233 [2]中国福利会国际和平妇幼保健院乳腺科,200030

出　　处：《实用癌症杂志》2011年第4期368-371,共4页The Practical Journal of Cancer

摘　　要：目的研究FHIT在乳腺良、恶性疾病组织中的表达特点,分析其与乳腺浸润性导管癌临床病理指标之间的关系。方法采用免疫组化SP法检测42例浸润性导管癌、8例导管内癌、16例导管上皮不典型增生、30例乳腺病病理标本Fhit蛋白的表达水平,并对其在各组织中的表达水平进行病理学观察和半定量分析。结果 Fhit蛋白在乳腺病、导管上皮不典型增生、导管内癌及浸润性导管癌组织中的表达阳性率逐渐降低,比较差异有统计学意义(P<0.01)。42例乳腺浸润性导管癌中有淋巴结转移组Fhit蛋白表达阳性率32.2%(8/25),显著低于无淋巴结转移组58.8%(10/17)(P<0.05);临床Ⅰ期、Ⅱ期、Ⅲ期浸润性导管癌Fhit蛋白阳性表达率分别为90.0%、43.7%、12.5%,比较差异有统计学意义(P<0.01);Fhit蛋白的表达与Cerb-B2的表达呈负相关,γs=-0.357(P<0.05);Fhit蛋白的表达与p53的表达呈正相关,γs=0.411(P<0.01)。Fhit蛋白的表达缺失与年龄、肿瘤的大小、组织学分级、ER、PR无明显相关性。结论 FHIT表达降低可能对乳腺癌的演化和进展具有一定作用;与浸润性导管癌的淋巴结转移、临床分期密切相关;与Cerb-B2、p53表达相关,可为乳腺癌的早期诊断、进一步治疗及预后判断提供理论依据。Objective To study the expression of FHIT in benign and malignant breast disease and its relationship with clinicopathological parameters in breast carcinoma.Methods The expression of FHIT was dectected by immunohistochemistry in 42 infitrating ductal carcinoma tissues,8 intraductal carcinoma tissues,16 atypical hyperplasia of ductal epithelium tissues and 30 mastopathia tissues,and run the pathologic observation and semiquantitative analysis of FHIT.Results The positive of FHIT in mastopathia tissues,atypical hyperplasia of ductal epithelium tissues,intraductal carcinoma tissues,infitrating ductal carcinoma tissues declinede by degrees.There is statistical difference between them（P〈0.01）.The positive expression rate（32.2%,8/25） of FHIT in breast carcinoma tissues with lymph node metastases was significantly lower than that（58.8%,10/17） with no lymph node metastases（P〈0.05）.The positive expression ate of FHIT was found in 90.0%（stage Ⅰ） 、43.7%（stage Ⅱ）、12.5%（stage Ⅲ）.There is statistical diference between them（P〈0.01）.The presence of FHIT and Cerb-B2 are negative correlation statistically and γs=-0.357（P〈0.05）.The presence of FHIT and P53 are positive correlation statistically and γs=0.411（P〈0.01）.No statistically significant difference between FIHT and age,tumor size,histological class,ER,PR was noted in invasive carcinoma.Conclusion These result suggest that the reduced expression of FHIT may play an important role in development and progression of breast carcinoma.There may be an association between expression of FHIT and lymph node metastases,TNM stage,high expression of Cerb-B2 and p53 alteration.It may offer guide to early diagnosis,futher treatment and prognosis diection.

关 键 词：乳腺癌 脆性组氨酸三联体基因 Cerb-B2 p53 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]