Foxp3-6054基因多态性与变应性结膜炎的关系  

Study on Foxp3-6054 polymorphisms in patients with allergic conjunctivitis

作　　者：杨瑞明[1] 赖荷[2] 沙翔垠[1] 陈卫芳[1] 陈盛强[3] 樊飞红[1] 

机构地区：[1]广州医学院第二附属医院眼科,广州510260 [2]广州医学院第二附属医院过敏反应科,广州510260 [3]广州医学院第二附属医院神经科学研究所,广州510260

出　　处：《广东医学》2011年第14期1828-1830,共3页Guangdong Medical Journal

基　　金：广东省科技计划项目(编号:2010B031600139)

摘　　要：目的探讨Foxp3-6054(deletion/ATT,rs5902434)基因与尘螨变应性结膜炎遗传易感性的相关性。方法应用PCR-SSP技术为63例无亲缘关系的尘螨变应性结膜炎患者和100例无血缘关系的健康汉族人行Foxp3-6054(deletion/ATT,rs5902434)基因分型。结果变应性结膜炎组的Foxp3-6054(deletion/ATT,rs5902434)基因型频率与对照组相比,差异无统计学意义(P>0.05)。结论 Foxp3-6054(deletion/ATT,rs5902434)位点基因多态性与变应性结膜炎不相关。Objective To investigate the distribution of Foxp3 - 6054 （ deletion/ATF, rs5902454） gene in patients with allergic conjunctivitis and its correlation with the disease. Methods PCR - SSP was carried out in 63 unrelated patients with allergic conjunctivitis and 100 matched healthy control of Han nationality for genotyping of Foxp5 -6054 （deletion/ATF, rs5902434 ） gene. Results There was no significant difference in Foxp3 -6054 （deletion/ATf, rs5902434） genetyping between allergic conjunctivitis patients and controls （ P 〉 0. 05 ）. Conclusion Foxp3 - 6054 （deletion/ATF, rs5902434） is not associated with allergic conjunctivitis.

关 键 词：尘螨 变应性结膜炎 Foxp3—6054(deletion/ATT rs5902434) 多态性 

分 类 号：R777.31[医药卫生—眼科]