拉坦前列腺素降低高眼压的临床疗效及安全性观察  

Clinical effect and safety of latanoprost in the treatment of high intraocular pressure

作　　者：张季瑾[1] 

机构地区：[1]天津市大港油田总医院眼科,天津300280

出　　处：《海南医学》2011年第15期45-46,共2页Hainan Medical Journal

摘　　要：目的探讨拉坦前列腺素(适利达)降低高眼压的临床疗效及安全性。方法将我院收治的高眼压及开角型青光眼患者46例(92眼)随机分为观察组和对照组,每组23例,观察组患者给予拉坦前列腺素1次/d;对照组患者给予噻吗心安2次/d,12周为一个疗程,观察两组患者治疗前后个时间段眼压波动情况。结果①治疗后两组患者眼压波动值明显降低(P<0.05)。②观察组患者夜间眼压及眼压波动值显著低于对照组(P<0.01);两组患者白天眼压差异无统计学意义(P>0.05)。③对照组患者治疗后心率降低,与治疗前比较差异有统计学意义(P<0.05),观察组心率与治疗前比较差异无统计学意义(P>0.05)。结论拉坦前列腺素具有良好的降眼压作用,且使用剂量小,不良反应小。Objective To investigate the efficacy and safety of latanoprost in the treatment of high intraocular pressure.Methods 46 patients with high intraocular pressure and open-angle glaucoma（92 eyes） were randomly divided into the study group and the control group,with 23 cases in each group.The patients in the study group were given latanoprost one time per day,and that in the control group were given timolo two times per day,12 weeks for a period.The intraocular pressure fluctuations before and after the treatment were observed.Results The intraocular pressure fluctuation of the patients in the two groups reduced significantly after treatment,compared with that before the treatment（P0.05）.The night intraocular pressure fluctuation of the patients in the study group were significantly lower than that of the control group（P0.01）,while the daytime intraocular pressure of the patients in the two groups showed no statistically significant difference（P0.05）.The heart rate after the treatment in the control group was significantly lower that that before the treatment（P0.05）,while that before and after the treatment in the study group showed no statistically significant differences（P0.05）.Conclusion Latanoprost can lower the intraocular pressure effectively,with a small dose and few adverse reactions.

关 键 词：开角型青光眼 高眼压 拉坦前列腺素 噻吗心安 

分 类 号：R775.2[医药卫生—眼科]