帕金森病患者血清中犬尿氨酸、犬尿喹啉酸及色氨酸的测定及临床意义  

Significance of kynurenine,kynurenic acid and trptophane in patients with Parkinson′s disease

作　　者：唐亚梅[1] 张付峰[2] 刘勇[3] 常丹丹[4] 任亚萍[1] 

机构地区：[1]中南大学湘雅二医院检验科,长沙410011 [2]中南大学湘雅医院老年病科,长沙410008 [3]中南大学湘雅二医院精神与卫生研究所,长沙410011 [4]中南大学湘雅医学院检验系,长沙410013

出　　处：《广东医学》2011年第13期1678-1681,共4页Guangdong Medical Journal

基　　金：国家自然科学基金资助项目(编号:30700260)

摘　　要：目的研究帕金森病(Parkinson's disease,PD)患者血清犬尿氨酸(kynurenine,KYN)、犬尿喹啉酸(kynurenic acid,KYNA)和色氨酸(trptophane,TRP)浓度及代谢改变,探讨其临床意义。方法采用高效液相色谱-荧光检测法(HPLC-FLD)检测16例首发PD患者、36例美多巴(Madopar)治疗PD患者2、0例正常对照人群血清KYN、KYNA和TRP的浓度,比较血清KYN、KYNA、TRP以及KYNA/KYN和KYN/TRP比值的差异性。结果美多巴治疗PD患者血清KYNA水平和KYNA/KYN比值较首发PD患者和正常对照人群显著升高(P<0.01);首发PD患者及美多巴治疗PD患者血清中TRP水平较正常对照人群显著升高(P<0.01)。结论采用HPLC-FLD检测PD患者血清中的KYN、KYNA及TRP的含量,可为帕金森病的临床诊断和药物治疗提供部分实验室依据。Objective To evaluate the serum kynurenine （KYN）, kynurenic acid （KYNA） and trptophane （TRP） in Parkinson＇s disease （PD） patients and healthy controls. Methods The serum KYN, KYNA and TRP levels in 16 first episode PD patients, 36 PD patients treated by Madopar and 20 age -matched healthy controls were measured by high peflormanee liquid chromatography- fluorescence （HPLC- FLD）. KYNA/KYN and KYN/TRP ratios were calculated. Results The serum KYNA level and KYNA/KYN in PD patients treated by Madopar were significantly higher than those in first episode PD patients and controls （ P 〈 0. 01 ）. The serum TRP levels in first episode or Madopar treated PD patients was significantly higher than that in controls （ P 〈 0.01 ）. Conclusion The serum KYN, KYNA and TRP levels in PD patients may be used for the diagnosis and treatment of PD.

关 键 词：帕金森病 犬尿氨酸 犬尿喹啉酸 色氨酸 高效液相色谱 

分 类 号：R741.02[医药卫生—神经病学与精神病学]