肾细胞癌微血管密度与癌细胞转移的相关性  

Correlation of microvessel density in renal cell carcinoma and carcinoma cell metastasis

作　　者：王忠[1] 刘本春[1] 张元芳[1] 丁强[1] 孔宪国 

机构地区：[1]上海医科大学附属华山医院泌尿外科,上海200040 [2]上海铁路中心医院泌尿外科

出　　处：《临床泌尿外科杂志》1999年第12期536-538,共3页Journal of Clinical Urology

摘　　要：目的：探讨肾细胞癌（肾癌）微血管密度与癌细胞转移的相关性，以寻找判断肾癌细胞转移的可靠指标。方法：用第八因子相关抗原（F8因子）的单克隆抗体对32例肾癌石蜡切片行免疫组织化学染色，计数200倍视野内染色的微血管数（即做血管密度）。根据临床和术后病理检查是否存在癌细胞转移将患者分为两组。结果：有癌细胞转移者平均微血管密度为76±29，无癌细胞转移者为44±20，两者间有显著性差异（P＜0．05）；logistic回归分析表明做血管密度与癌细胞转移有相关性。结论：微血管密度可作为判断肾癌转移的可靠指标。To investigate relationship between microvessel density and metastasis inrenal cell carcinoma. Methods: Tumor specimens from 32 patients with renal cell carcinoma(RCC) were stained by immunohis toche mis try with monocolonal antibody of F8 related antigen.Microvessels were counted in a 200 field in the most active areas of neovascularization. The patients were divided into two groups: metastasis group and non-metastasis group. Results: Microvessel density in metastasis group was 76±29, nonmetastasis group 44±20. There is sighficant difference (P＜0.05) and correlation between microvessel density and metastasis (Logisticcorrelation). Conclusious: Microvessel density would be a independent indicator of prognsis forjudging the probability of metastasis.

关 键 词：肾肿瘤 细胞癌 微血管密度 肿瘤转移 

分 类 号：R737.110.6[医药卫生—肿瘤]