应用免疫组化S-P法对鼻腔原发性恶性黑色素瘤的进行诊断和鉴别诊断  

Diagnosis and Differential Diagnosis on Primary Nasal Malignant Melanomo by Using S-P Immunohistochemical Method

作　　者：魏红权[1] 曹敏[1] 

机构地区：[1]浙江医科大学附属第二医院,310009

出　　处：《齐齐哈尔医学院学报》1999年第5期433-434,共2页Journal of Qiqihar Medical University

摘　　要：目的：探讨鼻腔原发性恶性黑色素病的诊断和鉴别诊断。方法：应用免疫络化S－P法对14例鼻腔原发性性黑色素瘤进行S^100、Vimentin、HMB45。LCA、GFAP、Cytokeratin、actin、myoglobin进行联合标记，并仔细观察HE组织切片的组织结构特点和细胞形态特点。结果：鼻腔原发恶性黑色素瘤的阳性结果，S^100I(14/14),Vimentin(14/14)、Vimentin（14/14）、HMB^45（12/14），而LCA、GFAP、Cytokeratin、actin及myo－globin均为阴性，且具有组织结构的多样性，细胞形态的复杂性等特点。结论：充分认识恶性黑色素瘤的多样性，结合多种免疫酶标，可提高确诊率。Objective: To investigate diagnosis and differential diagnosis of primary nasal malignantmelanoma. Methods: Slo., vimentin, HMB45, LCA, GFAI, cytokeratin, ectin and myoglobin in l4 cases ofprimary nasal malignant melanoma were detccted by using S - P in1munohistochen1ical method, and the char-actcristics of tissue structure and cell form was observed carcfully. ResuItS: &oo (l4/14 ), vimcntin(14/l4 )and HMB45(12/l4) were PoSitive with the diversity of tissuc structurc and thc complexity of ccll form, butLCA, GFAP, cytokeratin, actin and myoglobin wcre all negative. Conclusion: The diagnosis rate of primarynasal malignant melanoma can be raiscd by recognizing its diversity and combining immuno hi stoc hem ist ry.

关 键 词：黑色素瘤 病理 免疫组化 鼻腔肿瘤 诊断 

分 类 号：R739.620.4[医药卫生—肿瘤] R730.45[医药卫生—临床医学]