血浆置换术治疗慢加急性肝衰竭50例  

Plasma exchange for patients with acute-on-chronic liver failure:An analysis of 50 cases

作　　者：郑三菊[1] 郑化芝[1] 凌红芬[1] 王蕾[1] 

机构地区：[1]湖北医药学院附属人民医院,湖北省十堰市442000

出　　处：《实用肝脏病杂志》2011年第4期275-276,共2页Journal of Practical Hepatology

摘　　要：目的探讨血浆置换术治疗慢加急性肝衰竭的效果。方法 50例慢加急性肝衰竭(ACLF)患者在护肝、降酶、退黄等综合治疗的基础上进行血浆置换治疗,观察治疗前后肝功能、凝血功能的变化,比较早、中、晚期患者的疗效。结果治疗后病人的总胆红素、丙氨酸氨基转移酶、天门冬酸氨基转移酶较治疗前下降(P<0.01),凝血酶原时间缩短(P<0.01),凝血酶原活动度(PTA)升高(P<0.01),临床症状改善;50例患者中32例(64.0%)存活,ACLF早、中、晚期的有效率分别为95.8%、43.8%、20.0%,早期患者的疗效明显优于中期和晚期(P<0.01);治疗中无明显不良反应。结论血浆置换术治疗慢加急性肝衰竭安全、有效,早期患者疗效更佳。Objective To explore the therapeutic effect of plasma exchange in the treatment of patients with acute-on-chronic liver failure（ACLF）.Methods 50 patients with ACLF were treated with plasma exchange on the basis of routine treatment.The hepatic function,coagulation tests and improvements of clinical symptoms were compared.Results After treatment,the patients＇ total bilirubin,alanine aminotransferase,aspartate aminotransferase,prothrombin time decreased（P0.01）,prothrombin time activity（PTA）increased（P0.01）,and clinical symptoms improved.32 cases（64.0%）out of the 50 patients survived.The effective rates of early,middle and late stage of ACLF patients were 95.8%,43.8% and 20.0%,respectively.Conclusions Plasma exchange is safe and effective in treatment of patients with ACLF.

关 键 词：慢加急性肝衰竭 血浆置换术 疗效 

分 类 号：R575.3[医药卫生—消化系统]