新型邻甲酰胺基间苯二甲酰胺类化合物的设计合成及生物活性  

Design,Synthesis and Biological Activities of Novel Anthranilic Isophthaloyl Amide

作　　者：闫涛[1] 于观平[1] 熊丽霞[1] 于淑晶[1] 王素华[1] 李正名[1] 

机构地区：[1]南开大学元素有机化学国家重点实验室元素有机化学研究所,天津300071

出　　处：《高等学校化学学报》2011年第8期1750-1754,共5页Chemical Journal of Chinese Universities

基　　金：国家"九七三"计划项目(批准号:2010CB126106);国家自然科学基金(批准号:20872069)资助

摘　　要：以氯虫酰胺结构为基础,设计合成了一系列新型邻甲酰胺基间苯二甲酰胺类化合物,所有化合物均通过核磁共振氢谱和高分辨质谱表征确定.初步的生物活性测试结果表明,在浓度为200 mg/L时,化合物8d的杀粘虫活性可达60%;在浓度为50 mg/L时,化合物8d对苹果轮纹病菌的抑菌率为41.7%,化合物8a对小麦赤霉菌的抑菌率为41.2%.Chlorantraniliprole has been widely studied in the agrochemical field,which is significant in the field of crop protection,particularly important in light of the ability of insects to rapidly develop resistance and the need for safe and effective pesticides that act at Ryanodine receptor.A series of novel anthranilic isophthaloyl amides developed from the structure of chlorantraniliprole was designed and synthesized.Their structures were characterized by 1H NMR and HR-MS.The preliminary results of biological activity experiment showed that compound 8d exhibited 60% insecticidal activity against Mythimna separata Walker at a concentration of 200 mg/L;compound 8d exhibited 41.7% fungicidal activity against Physalospora piricola and compound 8a exhibited 41.2% fungicidal activity against Gibberella sanbinetti at a concentration of 50 mg/L.

关 键 词：氯虫酰胺 邻甲酰胺基间苯二甲酰胺 杀虫活性 抑菌活性 

分 类 号：O626.3[理学—有机化学]