黄花败酱的化学成分研究  

Chemical constituents of Patrinia scabiosaefolia

作　　者：高亮[1] 张琳[2] 刘江云[1] 蔡培烈[1] 杨世林[1] 

机构地区：[1]苏州大学药学院,江苏苏州215123 [2]浙江大学生物医学工程与仪器科学学院,浙江杭州310027

出　　处：《中草药》2011年第8期1477-1480,共4页Chinese Traditional and Herbal Drugs

摘　　要：目的研究黄花败酱Patrinia scabiosaefolia的化学成分。方法采用甲醇提取、溶剂萃取、硅胶柱色谱法、Sephadex LH-20凝胶柱色谱法、中压快速制备及半制备高效液相色谱等方法分离纯化;通过化学方法及核磁共振谱、质谱等光谱数据鉴定化合物结构。结果分离得到14个化合物,分别鉴定为3-羟基-11-氧代齐墩果酸(1)、3,11-二氧代齐墩果酸(2)、3-O-木糖-齐墩果酸-28-葡萄糖酯苷(3)、3-氧代-29-羟基齐墩果酸(4)、3β,12α-二羟基-13β,28-内酯齐墩果酸(5)、3-鼠李糖-(1→2)-木糖-齐墩果酸-28-葡萄糖酯苷(6)、愈创木-6(7)-烯-4,10-二醇(7)、3α-乌苏酸(8)、豆甾醇(9)、麦角甾-6,22-二烯-3β,5α,8α-三醇(10)、齐墩果酸-3-O-β-D-吡喃木糖苷(11)、齐墩果酸-3-O-鼠李糖-(1→2)-木糖苷(12)、3-O-木糖-(1→3)-鼠李糖-(1→2)-阿拉伯糖-齐墩果酸-28-葡萄糖酯苷(13)、齐墩果酸-28-O-葡萄糖-(1→6)-葡萄糖酯苷(14)。结论化合物1～8均为首次从本属植物中分离得到。Objective To study the chemical constituents of Patrinia scabiosaefolia. Methods The constituents were extracted by methanol and isolated by silica gel chromatography, Sephadex LH-20 gel column chromatography, medium pressure column chromatography, and semi-preparative high performance liquid chromatography. Their structures were elucidated by chemical properties and spectroscopic analysis. Results Fourteen compounds were isolated and their structures were identified to be 3-hydroxy-olean-ll-oxo-12-en-28-oic acid （1）, 3, ll-dioxoolean-12-en-28-oic acid （2）, 3-O-β-D-xylopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester （3）, 29-hydroxy-3-oxo-olean-12-en-28-oic acid （4）, 3β, 12α-dihydroxy-oleanan-13β, 28-olide （5）, 3-O-rhamnopanosyl-（1→2）-xylopyanosyl-oleanolic acid-28-O-glucopyanosyl ester （6）, guaia-6-en-4, 10-diol （7）, 3-epi-ursoloic acid （8）, stigmaSterol （9）, ergost-6, 22-alien-3β, 5α, 8α-triol （10）, oleanolic acid 3-O-β-D-xylopyranoside （11）, oleanolic acid 3-α-L-rhamnopyanosyl-（1→2）-β-D-xylopyranoside （12）, 3-O-β-D-xylopyanosyl-（1→ 3 ）-α-L-rahmnopyanosyl-（1→2 ）-a-L-arabino- pyanosyl oleanolic acid 28-O-β-D-glucopyranosyl ester （13）, and oleanolic acid 28-O-β-D-glucopyranosyl-（1→6）-β-D- glucopyranosyl ester （14）. Conclusion Compounds 1--8 are obtained from the plants ofPatrinia Juss. for the first time.

关 键 词：黄花败酱 败酱属 三萜皂苷 3-羟基-1 1-氧代齐墩果酸 愈创木一6(7)-烯一4 1 0一二醇 

分 类 号：R284.1[医药卫生—中药学]