1995—2008年北京医院前列腺癌诊断状况变迁  

Trend of prostate cancer diagnosed in Beijing Hospital from 1995 to 2008

作　　者：刘明[1] 王建业[1] 万钢 王鑫[1] 王建龙[1] 陈鑫[1] 马宏[1] 朱生才[1] 魏东[1] 万奔[1] 张力青[1] 

机构地区：[1]卫生部北京医院泌尿外科,100730 [2]北京市地坛医院病案统计室

出　　处：《中华泌尿外科杂志》2011年第8期535-538,共4页Chinese Journal of Urology

基　　金：北京市科技计划项目（Z090507017709003）;首都医学发展科研基金项目（2009-3019）

摘　　要：目的了解血清前列腺特异抗原（PSA）临床应用推广后前列腺癌诊断状况的变化。方法回顾性分析1995—2008年北京医院新诊断的前列腺癌病例资料，对诊断例数、确诊年龄、PSA水平以及临床分期状况进行分析。结果14年间共新诊断前列腺癌患者432例，确诊年龄40～90岁，平均（72．0±7．8）岁。新诊断例数逐年增加，尤以2007—2008年显著。与1995—1999年相比，2004—2008年局限性前列腺癌比例由23．9％上升至36．3％，转移性前列腺癌比例由49．3％下降至32．1％；PSA4～10ng／ml者比例由12．7％上升至29．2％，PSA〉100ng／ml者比例由22．5％下降至13．2％。结论1995—2008年北京医院新诊断前列腺癌例数上升，早期诊断率增加，诊断年龄无明显偏移。前列腺癌的早期诊断率仍有待提高。Objective To evaluate the morbidity trend of prostate cancer since the clinical usage of PSA was introduced in Beijing Hospital. Methods Retrospectively we analyzed prostate cancer cases diagnosed in Beijing Hospital from 1995 to 2008. The incidence, age, PSA and clinical stage at diagnosis were taken into account. Results Four hundred and thirty-two cases were enrolled into the study. Who were aged 40 - 90 years old, mean age 72.0 - 7.8 years. The most frequent age at diagnosis was 70 to 79 years. The incidence increased annually with the most significant increase taking place in 2007 and 2008. Compared with the period 1995 to 1999, the localized prostate cancer rate between 2004 and 2008 increased from 23.9% to 36.3% ; the metastatic prostate cancer rate decreased from 49.3% to 32.1% ; the rate of patients with PSA 4 - to rig/m1 increased from 12.7% to 29.2% ; the rate of PSA 〉 100 ng/ml decreased from 22.5% to 13.2%. Conclusions The incidence and early detection rate of prostate cancer in Beijing Hospital increased from 1995 to 2008. The age at diagnosis had not significantly changed. However, the early detection rate should be improved.

关 键 词：前列腺肿瘤 癌 早期诊断 回顾性研究 

分 类 号：R737.25[医药卫生—肿瘤]