纳米磁流体靶向栓塞食道曲张静脉破裂出血的研究  

Targeted embolization of esophagus varix hemorrhage with nano-magnetic fluid

作　　者：汤照峰[1] 潘楚芝[1] 方和平[1] 邓美海[1] 凌云彪[1] 许瑞云[1] 

机构地区：[1]中山大学附属第三医院肝胆外科,广州510630

出　　处：《中华实验外科杂志》2011年第8期1337-1338,F0004,共3页Chinese Journal of Experimental Surgery

基　　金：基金项目：广东省科技计划资助项目（2006836003010）;广东省自然科学基金资助项目（05300725）

摘　　要：目的观察纳米磁流体靶向栓塞食道曲张静脉破裂出血的止血效果及安全性。方法将10条食道静脉曲张破裂出血动物模型（犬）随机分为栓塞治疗组和对照组，治疗组经股静脉注射吸附纤维蛋白原的磁流体10mI，食道内磁控30min，观察出血量及止血时间，并取食道、脑组织、肝、肺、肾、心肌进行病理学检查。结果治疗组出血量（46±18）ml小于对照组（66±15）ml，差异有统计学意义（P〈0．05）。治疗组止血时间（4．60±0．44）min小于对照组（5．00±0．52）min，差异有统计学意义（P〈0．05）。病理学检查发现治疗组食道黏膜下静脉及穿支静脉血栓形成，脑组织、肝、肺、肾、心肌均未发现异位栓塞。结论纳米磁流体可以用于食道曲张静脉破裂出血的靶向栓塞，缩短止血时间，减少出血量，避免发生异位栓塞。Objective To observe the hemostasis effect and safety of targeted embolization of esophagus varix hemorrhage with nano-magnetic fluid. Methods Ten canine models of esophagus varix hemorrhage were randomly divided into embolotherapy group and control group. In embolotherapy group, 10 ml nano-magnetic fluid treated with fibrinogen was injected through vena femoralis and exposed to magnetic field for 10 min. Bleeding volume and hemostasis effect were recorded. Pathological changes of the esophagus, brain, liver, lung, kidney and myocardium were observed. Results Bleeding volume in embolotherapy group （46 ± 18） ml was less than in control group （66 ± 15） ml （P 〈0. 05）. Hemostasis time in embolotherapy group （4. 60 ±0. 44） min was shorter than in control group （5.00 ±0. 52） min （P 〈0. 05）. Thromboses were found in the submucosal vein and perforating branch vein of embolotherapy group. However, no thrombosis was found in the brain, liver, lung, kidney and myocardium. Conclusion Nano-magnetic fluid can be used for targeted embolization of esophagus varix hemorrhage to promote hemostasis and avoid allotopia thrombosis.

关 键 词：门静脉/高血压 栓塞治疗 

分 类 号：R575.2[医药卫生—消化系统]