膜细胞骨架连接蛋白(Ezrin)和bcl-2在胃癌中的表达及临床意义  

Clinical significance and expression of Ezrin and bcl-2 in gastric carcinoma

作　　者：程翌[1] 徐维田[1] 熊毅敏[1] 黄海涛[1] 高娟[1] 郑国荣[1] 

机构地区：[1]广州军区武汉总医院消化内科,武汉430070

出　　处：《医药论坛杂志》2011年第12期22-24,共3页Journal of Medical Forum

摘　　要：目的探讨膜细胞骨架连接蛋白(ezrin)和bcl-2分子在人胃癌组织中的表达,并分析ezrin、bcl-2与胃癌临床病理特征的关系及两者的相关性。方法应用免疫组化SP法检测ezrin、bcl-2在58例胃癌及胃正常组织中的表达,分析其与胃癌临床病理参数的关系和两者的相关性。结果 ezrin在胃癌组织表达的阳性率为63.9%(37/58),而在胃正常组织表达的阳性率为25%(5/20),差异有统计学意义,ezrin的表达和胃癌TNM分期和淋巴结转移相关;bcl-2在胃癌组织表达阳性率为65.5%(38/58),在胃正常组织表达的阳性率为30%(6/20),差异有统计学意义,bcl-2的表达和胃癌TNM分期相关。ezrin和bcl-2的在胃癌中表达呈正相关。结论 ezrin参与胃癌的发生,可能和影响bcl-2的表达有关。Objective To explore the expression of ezrin and bcl-2 in gastric carcinoma and analyze the relationship between their expression and clinicopathological characteristics.Methods A series of 58 gastric carcinomas,20 normal gastric mucosal samples were examined for the expression of Ezrin and bcl-2 using immunohistochemistry.The correlation and clinical significance were analyzed.Results The positive rates of Ezrin protein were 25.0 %（5/20）,63.9%（37/58）in normal gastric tissues and gastric carcinoma,and that of bcl-2 protein were 30%（6/20）and 65.5%（38/58）,respectively.The expression of Ezrin was correlated to the clinical stage and lymph nodemetastasis,while the expression of bcl-2 was correlated to the clinical stage.The expression of ezrin was positively correlated to that of bcl-2 in gastric carcinoma（rp=0.785）.Conclusions The expression rate of ezrin and bcl-2 were higher in gastric carcinoma.They may play an important role in the development of gastric carcinoma.Further analysis on the pathways downstream of ezrin are warranted.

关 键 词：胃癌 膜细胞骨架连接蛋白(ezrin) BCL-2 细胞凋亡 

分 类 号：R735.2[医药卫生—肿瘤]