低氧诱导因子1α的结构、调控及其在肿瘤形成过程中的作用  

The structure and regulation of HIF-1α and its role in tumorigenesis

作　　者：霍瑞雪[1] 韩婷婷[1] 胡静雯[2] 

机构地区：[1]中国医科大学附属盛京医院学生科,辽宁沈阳110004 [2]中国医科大学七年制临床医学,辽宁沈阳110004

出　　处：《中国医药导报》2011年第23期7-9,共3页China Medical Herald

摘　　要：低氧诱导因子(hypoxia-inducible factors,HIF)是细胞氧气信号传导通路的重要介质,而HIF-1α是目前被认为最重要且研究得最透彻的一种。由于肿瘤细胞的代谢比正常细胞更加旺盛,其对氧气及其他营养物质的需求也更多,因此低氧是大多数实体肿瘤的主要特征之一。低氧条件下,HIF-1α呈现出高表达,它在调控细胞糖代谢、血管生成、红细胞生成、肿瘤细胞增殖、代谢、侵袭和转移等方面的重要作用,已使它被公认为是肿瘤生长的促进因子,而其失活也可导致肿瘤生长的抑制。Hypoxia-inducible factors （HIF） are essential mediators of the cellular oxygen-signaling pathway, while HIF-1α is considered the most important and the most thorough studied one. Because the metabolism of tumor cells are more vigorous than normal cells, it demands for more oxygen and other nutrients. Thus hypoxia is one of the main features of solid tumor. In condition of hypoxia, the expression of HIF-1α is generally high. HIF-1αplays an important role in the regulation of cellular glucose metabolism, angiogenesis, erythropoiesis, cell proliferation and apoptosis. And it has been recognized as a positive regulator of tumor growth as its inhibition often results in tumor suppression.

关 键 词：缺氧诱导因子-1Α 肿瘤生成 结构 调控 

分 类 号：R730.231[医药卫生—肿瘤]