胰腺导管腺癌中CD74的表达及临床意义  

Clinical significance of CD74 expression in pancreatic ductal adenocarcinoma

作　　者：史敏[1] 陈颖[1] 赵晨燕[1] 张晶[1] 倪灿荣[1] 朱明华[1] 

机构地区：[1]第二军医大学长海医院病理科,上海200433

出　　处：《临床与实验病理学杂志》2011年第7期689-692,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：国家自然科学基金(30770996);国家科技支撑计划(2006BAI02A14)

摘　　要：目的检测CD74蛋白在胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)组织中的表达并探讨其临床意义。方法收集59例PDAC和23例慢性胰腺炎(chronic pancreatitis,CP)的存档石蜡包埋标本。HE染色、镜下观察神经纤维周围淋巴细胞病灶。免疫组化检测CD74的表达,统计分析其与PDAC临床病理参数的关系。结果 PDAC神经纤维周围淋巴细胞病灶发生率为67.8%。CD74在肿瘤细胞中阳性表达率为61%(36/59),明显高于CP导管上皮(13%,3/23,P=0.000)。CD74表达与神经纤维淋巴细胞病灶密切相关(P=0.009),与其它临床病理参数无关。CD74阳性的PDAC患者术后生存时间明显短于CD74阴性患者(P=0.006 9)。CD74在肿瘤细胞中的表达(P=0.009;rs=2.590)及pT(P=0.022;rs=1.482)为影响PDAC患者预后的独立危险因素。结论 CD74在胰腺导管腺癌组织中高表达与神经纤维周围淋巴细胞病灶及肿瘤预后相关,可能成为PDAC预后相关的分子靶标。Purpose To examine CD74 expression and discuss its clinical significance in pancreatic ductal adenocarcinoma（PDAC）.Methods 59 achival cases of PDAC and 23 of chronic pancreatitis（CP） were analyzed with microscopic and immunihistochemical assay.Foci of lymphocytes around nerve fibers were observed after hematoxylin-eosin staining and CD74 expression was examined by immunohistochemistry.Relationship between CD74 expression and clinicopathological parameters was analyzed by statistical methods.Results Foci of lymphocytes around nerve fibers was observed in 67.8%（40/59） of PDACs.CD74 expression was positive in cancer cells of PDACs（61%,36/59）,which was significantly higher than normal ductal epithelium in CP（13%,3/23）（P=0.000）.CD74 expression was significantly associated with foci lymphatic infiltration around nerves（P=0.009）,but not with other clinico-pathologic parameters.Survival time of PDACs with CD74 positivity was significantly shorter than CD74-negative cases（P=0.006 9）.Cox analysis showed that CD74 expression（P=0.009;relative risk,2.590） and pT（P=0.022;relative risk,1.482） were independent prognositic indicators in PDAC.Conclusions The over-expression of CD74 in PDAC is related with foci lymphatic infiltration around nerves and prognosis and might be a promising target for PDAC therapy.

关 键 词：胰腺肿瘤 胰腺导管腺癌 CD74 免疫组化 预后 

分 类 号：R735.9[医药卫生—肿瘤]