小儿腹部恶性肿瘤的介入治疗  

Interventional treatment of abdominal malignant neoplasm in children

作　　者：庄文权[1] 刘钧澄[1] 杨建勇[1] 陈伟[1] 张翎[1] 李家平[1] 李桂生[1] 

机构地区：[1]中山医科大学附属第一医院放射科,广州510080

出　　处：《癌症》1999年第6期717-719,共3页Chinese Journal of Cancer

摘　　要：目的 :探讨对一期手术切除困难的腹部恶性肿瘤术前行介入治疗的意义。材料和方法 :对 13例腹部恶性肿瘤进行介入治疗 ,肝母细胞瘤 6例 ,神经母细胞瘤 4例 ,肾母细胞瘤 2例 ,肾上腺皮质癌 1例。所有病例先行动脉插管造影 ,确定肿瘤主要供血动脉 ,对肿瘤供血动脉行超选择性插管 ,局部注入化疗药物及栓塞剂。结果 :13例中 7例手术切除了肿瘤 ,1例剖腹探查。余 5例通过介入治疗后 ,肿瘤缩小。 13例病人随访 6～ 13个月 ,生存11例。结论 :介入治疗可保证肿瘤局部高浓度化疗药物灌注 ,减少全身副作用 ;又可阻断肿瘤血供 ,使肿瘤缺血坏死 ,达到治疗目的。同时栓塞后 ,肿瘤包膜增厚 。Objective:To investigate the significance of interventional treatment before radical resection of the abdominal neoplasm in children Methods:ALL of 13 patients with abdominal malignant tumor received interventional therapy They were 6 cases of hepatoblastoma, 4 of neuroblastoma, 2 of nephroblastoma and 1 of adrenocortical carcinoma The procedure was transarterial chemoembolotherapy In the procedures precise arterography was performed to find out the feeding artery of the malignancy And then superselective catheterization of those arteries was perfomed to obtanin better therapeutic results Gelform particles and lipid iodine were applied in the embolization Results:The neoplasms were entirely removed in 7 cases out of 13 In the other 6 patients, the tumors were unresectable The tumors shrank after the interventional chemoembolotherapy in 5 patients Eleven patients out of 13 survived till now in the 18 months follow up period Conclusions:Interventional treatment (transarterial chemoembolotherapy) will ensure the high dose chemotherapy to be given, and decrease the systemic side effects Embolization blocks the arterial supply of tumor, which results in the ischemia and necrosis of the tumor And the malignant neoplasms will be thickly capsulated after interventional procedures,making radical resection possible

关 键 词：恶性肿瘤 儿童 腹部肿瘤 介入疗法 

分 类 号：R735.05[医药卫生—肿瘤] R730.55[医药卫生—临床医学]