MTDH与肿瘤关系的研究进展  

Progress in research of MTDH and its relation with tumors

作　　者：王启明[1] 谢晓冬[1] 

机构地区：[1]沈阳军区总医院肿瘤科,辽宁沈阳110016

出　　处：《中华肿瘤防治杂志》2011年第14期1138-1140,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：辽宁省自然科学基金(20082070)

摘　　要：目的:总结异黏蛋白(MTDH)的功能及其作用的分子机制,探讨MTDH与肿瘤的关系。方法:应用Medline、PubMed及CNKI期刊全文数据库检索系统,以"MT-DHt、umor"等为检索词,检索2005-2010年相关文献29条。纳入标准:1)MTDH的功能;2)MTDH作用机制;3)MTDH与肿瘤的关系。根据纳入标准,符合分析的文献18篇。结果:MTDH基因在肿瘤进展中起着重要的作用,包括促进肿瘤细胞增殖、侵袭和转移、避免凋亡及促使肿瘤细胞对化疗药物产生耐药。MTDH通过激活NF-κB、PI3K/AKT、MAPK与wnt/-βcatenin信号通路来促进肿瘤的发生发展。结论:深入研究MTDH在恶性肿瘤中的表达及功能有助于理解肿瘤发生发展的分子机制。MTDH基因有望成为治疗肿瘤的有效靶点。OBJECTIVE： To summarize the function of MTDH and molecular mechanism of MTDH,and explore the relationship between MTDH and tumor.METHODS： A total of 29 English papers were searched with MTDH and tumor as in Medline and Pubmed databases from 2005 to 2010.Eighteen papers were selected according to the standards as follows： 1）The function of MTDH;2）The molecular mechanism of MTDH action;3）The relationship between the MTDH and tumors.RESULTS：MTDH plays a functional role in several crucial aspects of tumor progression,including invasion,metastasis,evasion of apoptosis and chemoresistance.MTDH contributes to the occurrence and development of malignant tumors by activating NF-κB,PI3K/AKT,MAPK and wnt/β-catenin signal pathways.CONCLUSIONS： Further research on the expression and function of MTDH in carcinomas will contribute to extensive understanding of the molecular mechanism of tumorigenesis.MTDH may become a potentially valuable target in cancer treatments.

关 键 词：异黏蛋白 信号通路 肿瘤 综述文献 

分 类 号：R730.2[医药卫生—肿瘤]