儿童及青少年卵巢肿瘤187例  

Clinical Analysis of Ovarian Tumors in 187 Children and Adolescents

作　　者：童文侠[1,2] 吴正清[3] 丁文[1,2] 李艳芳[1,2] 

机构地区：[1]中山大学肿瘤防治中心妇科,广州510060 [2]华南肿瘤学国家重点实验室,广州510060 [3]皖南医学院弋矶山医院甲乳外科,安徽芜湖241001

出　　处：《实用儿科临床杂志》2011年第15期1185-1187,共3页Journal of Applied Clinical Pediatrics

基　　金：中山大学临床医学研究5010计划(2007044)

摘　　要：目的探讨儿童及青少年卵巢肿瘤的发病特点、病理类型与发病年龄的关系,并评价其诊治手段及预后因素。方法选取1980年1月-2005年12月在中山大学肿瘤防治中心治疗并确诊的儿童及青少年卵巢肿瘤患儿187例,并对其临床及随访资料进行回顾性分析。采用SPSS 13.0统计软件,定性变量比较采用χ2检验,生存率计算用寿命表法。采用Kaplan-Meier法进行生存分析。结果 187例卵巢肿瘤中良性56例,恶性119例,交界性12例。不同病理类型的卵巢肿瘤与患儿发病年龄有一定关系(χ2=12.396,P=0.015)。187例卵巢肿瘤中,56例良性肿瘤5 a总生存率为98%,119例恶性肿瘤5 a总生存率为76%,12例交界性肿瘤5 a生存率为83%。单因素生存分析显示,影响总生存时间的危险因素为肿瘤分期、是否行规范化疗和化疗方案。结论超声及CT是卵巢肿瘤诊断的主要方法。不同病理类型的儿童卵巢肿瘤与发病年龄有一定关系。肿瘤分期、术后辅助治疗方式均影响患儿总生存时间。Objective To explore the clinical characteristics of children and adolescents diagnosed as ovarian tumors,and the relations between pathological characteristics and age of onset.To discuss the diagnostic measures as well as treatment and to evaluate the diagnosis,treatment and prognostic factors.Methods A total of 187 children and adolescents diagnosed as ovarian tumors and treated in Sun Yat-Sen University Cancer Center from Jan.1980 to Dec.2005 were selected and retrospectively analyzed.Statistical data were analyzed with SPSS 13.0 software.Qualitative data was analyzed by Chi-square test and survival rate was calculated by life table method.Kaplan-Meier method was performed to evaluate the prognostic factors in univariate analysis.Results There were 56 patients with benign tumor,119 patients with malignant and 12 patients with borderline tumor in 187 children with ovarian tumors.Specific relations were found between pathological characteristics and age of onset（χ2=12.396,P=0.015）.Among 187 cases,56 patients with benign tumor the 5-year survival rate was 98%.The 5-year survival rate of the 119 patients with malignant neoplasm was 76%.And the 12 patients with borderline tumor was 83%.Univariate analysis indicated the prognostic factors of malignant ovarian tumors were tumor staging,standard chemotherapy and chemotherapy regimens.Conclusions Ultrasound and CT are the major options for diagnosis.There are specific relations between pathological characteristics and age of onset.Adjuvant therapy and tumor staging are prognostic factors to malignant ovarian tumors.

关 键 词：卵巢肿瘤 病理类型 生存分析 预后因素 

分 类 号：R737.31[医药卫生—肿瘤]