周围型肺癌病理、CT表现与血清肿瘤标志物CEA关系研究  

Correlation study of CT features,pathology and the serum CEA concentration in peripheral lung cancer

作　　者：谭理连[1] 周洁[1] 李志铭[1] 江金带[1] 李树欣[1] 张婉红[1] 

机构地区：[1]广州医学院第二附属医院CT室,广东广州510260

出　　处：《中国临床医学影像杂志》2011年第7期464-467,共4页Journal of China Clinic Medical Imaging

基　　金：广州市属高校科技计划项目(61028);广东省医学科研基金项目(A2004298);广州医学院博士启动基金项目(0706073)

摘　　要：目的:探讨周围型肺癌病理、CT表现与血清肿瘤标志物CEA浓度的相关性。方法:回顾性分析48例周围型肺癌病理、CT表现与血清肿瘤标志物CEA资料,对比分析其病理、CT表现与血清肿瘤标志物CEA关系。结果:30例腺癌CEA浓度为(13.23±20.47)ng/ml,11例鳞癌CEA浓度为(3.62±2.48)ng/ml,腺癌与鳞癌血清CEA浓度差异有统计学意义。肺癌的分化程度与血清肿瘤标志物CEA浓度相关系数r值为-0.017。有深分叶征或瘤体直径≥3cm的肺癌,其血清CEA浓度较无深分叶征或瘤体直径<3cm高。肺癌有无胸膜凹陷征、毛刺征、支气管气相、增强值≥20HU、空洞、空泡征、毛玻璃征、钙化或肺门、纵隔淋巴结肿大与其血清CEA浓度差异无统计学意义。肺癌Ki-67抗原阳性百分率与血清CEA浓度之间有正相关关系(r=0.576)。26例p53表达阳性肺癌CEA浓度(19.37±24.40)ng/ml,22例p53表达阴性肺癌CEA浓度(3.64±2.11)ng/ml,二者血清CEA浓度差异有统计学意义。结论:肺癌的深分叶征、瘤体直径≥3cm、Ki-67抗原及p53蛋白表达与其血清CEA浓度有一定正相关性,肺癌的分化程度与血清CEA浓度之间差异无统计学意义。Objective：To discuss the correlation of pathology,CT features and serum CEA concentration in peripheral lung cancer.Materials and Methods：The pathology,CT features and the serum CEA concentration in 48 cases of peripheral lung cancer,confirmed by operation and pathology,were analyzed.Results：The serum CEA concentration was（13.23±20.47）ng/ml（adenocarcinoma,n=30）,（3.62±2.48）ng/ml（squamous carcinoma,n=11）.There was no correlation between the serum CEA concentration and the tumor differentiation degree in lung cancer（r=-0.017）.The serum CEA concentration were higher in lung cancer with deep lobulation sign or diameter≥3cm.There was no significant difference between lung cancer with pleural indentation sign,spiculation sign,increased CT value≥20HU after enhancement,calcification or enlargement of hilar or mediastinal lymph nodes and serum CEA concentration.There was positive correlation between the percentage of Ki-67 antigen and the serum CEA concentration in lung cancer（r=0.576）.The serum CEA concentration was（19.37±24.40）ng/ml（p53 positive group）,（3.64±2.11）ng/ml（p53 negative group）.Conclusion：There was positive correlation between serum CEA concentration,the percentage of Ki-67 antigen,expression of p53,deep lobulation sign and diameter≥3cm of peripheral lung cancer.There was no significant difference between tumor differentiation degree and serum CEA concentration in peripheral lung cancer.

关 键 词：肺肿瘤 癌胚抗原 体层摄影术 螺旋计算机 

分 类 号：R734.2[医药卫生—肿瘤] R730.43[医药卫生—临床医学]