5-HT在肠易激综合征发病机制中的研究现状  

Current Status of Study on 5-HT in the Pathogenesis of Irritable Bowel Syndrome

作　　者：周应初[1] 周鹤俊[1] 刘斌[1] 

机构地区：[1]中南大学湘雅二医院消化内科,410011

出　　处：《胃肠病学》2011年第7期445-448,共4页Chinese Journal of Gastroenterology

摘　　要：肠易激综合征(IBS)是常见的功能性胃肠病之一,其发生与5-羟色胺(5-HT)系统的功能改变密切相关。5-HT系统功能改变通常包括5-HT受体及其亚型、5-HT转运体(SERT)及其多态性等改变,参与调节胃肠道感觉、运动、分泌等功能,并与精神心理活动异常密切相关。本文就5-HT在IBS发病机制中的研究现状作一综述。Irritable bowel syndrome （IBS） is one of the common functional gastrointestinal disorders, its pathogenesis is closely related to the functional changes of 5-hydroxytryptamine （5-HT） system. The functional changes of 5-HT system usually include the changes of 5-HT receptors and their subtypes, serotonin transporter （SERT） and its polymorphism, which are involved in the regulation of gastrointestinal sensation, motion, secretion, ete, and are closely related to the abnormality in psychology. This article reviewed the current status of study on 5-HT in the pathogenesis of IBS.

关 键 词：肠易激综合征 血清素 受体 血清素 

分 类 号：R574[医药卫生—消化系统]