红景天对肝硬化性心肌病治疗作用的临床研究  

A Clinical Study of Therapeutical Effect of Rhodiola Rosae on Cirrhotic Cardiomyopathy

作　　者：王小红[1] 薛祥龙[1] 张东军[2] 俞建家[2] 徐国栋[2] 李宏良[2] 潘新梅 张锁林[1] 

机构地区：[1]江苏省丹阳市人民医院消化内科,212300 [2]江苏省丹阳市人民医院消感染科,212300

出　　处：《天津医药》2011年第8期688-691,共4页Tianjin Medical Journal

基　　金：镇江市2009年度社会发展指导性科技计划项目(项目编号:FZ2009003)

摘　　要：目的:观察红景天对肝硬化性心肌病(CCM)的治疗作用。方法:将40例CCM患者随机分为A组(20例)和B组(20例),同时以健康志愿者20例作为正常对照组(C组)。A组采用常规治疗,B组采用常规治疗+红景天治疗,以硝酸还原酶法测定血清NO浓度,以电化学发光法测定血浆N-末端脑钠肽前体(NT-proBNP)浓度,以彩色多普勒超声测定左室射血分数(LVEF)及舒张早期/晚期最大血流速度(E峰/A峰,E/A)比值。结果:A组及B组入院时LVEF、E/A比值显著低于C组,而血浆NT-proBNP及血清NO浓度则显著高于C组(P<0.001);A、B2组入院时、治疗10d、30d、90d比较,血浆NT-proBNP及血清NO浓度逐步下降(P<0.01)。B组治疗10d、30d及90d比较,LVEF及E/A比值于治疗10、30、90d逐步上升(P<0.01)。B组治疗30d与90dLVEF、E/A比值均高于A组,而血浆NT-proBNP浓度和NO均低于A组,B组治疗10d血清NO浓度低于A组(P<0.05或P<0.01)。结论:红景天对CCM有较好的治疗作用。Objective：To explore the effects of Rhodiola Rosae in treatment of patients with cirrhotic cardiomyopathy（CCM）.Methods：A total of 40 patients with CCM were randomly divided into group A（n=20） treated with routine method and group B（n=20） treated with Rhodiola Rosae capsule and routine method,respectively.Twenty normal individuals were used as normal controls（group C）.The serum level of nitric oxide（NO） was measured by the method of nitric acid reductase.The plasma level of N-terminal pro-brain？natriuretic peptide（NT-proBNP） was measured by the method of electrogenerated chemiluminescence.The value of left ventricular ejection fraction（LVEF） and the ratio of early diastolic/late？peak velocity（E/A） were measured by color Doppler.Results：The value of LVEF and the ratio of E/A were significantly lower,while the levels of serum NO and plasma NT-proBNP were significantly higher on admission in group A and group B compared with those of group C（P 0.01）.The levels of serum NO and plasma NT-proBNP were gradually decreased on admission 10 d,30 d and 90 d after treatment in group B（P 0.01）.The value of LVEF and the ratio of E/A were gradually increased 10 d,30 d and 90 d after treatment in group B（P 0.01）.The value of LVEF and the ratio of E/A were significantly higher,but the plasma levels of NT-proBNP and NO were significantly lower after 30-day and 90-day treatment in group B,compared with those of group A.The serum levels of NO were significantly lower after 10 d treatment in group B than those of group A（P 0.05 or P 0.01）.Conclusion：The results suggested that Rhodiola Rosae can play a therapeutic role in CCM.

关 键 词：红景天 肝硬化 心肌疾病 利钠肽 脑 一氧化氮 超声检查 多普勒 彩色 

分 类 号：R575.2[医药卫生—消化系统]