血浆可溶性髓样细胞触发受体-1水平在脓毒症监测中的意义  

Clinical Significance of sTREM-1 in Sepsis

作　　者：王洪霞[1] 刘健[1] 张璐[1] 

机构地区：[1]天津医科大学第二医院急诊科,300211

出　　处：《天津医药》2011年第8期717-719,共3页Tianjin Medical Journal

基　　金：天津市卫生局科技基金资助项目(项目编号:09KZ93)

摘　　要：目的:探讨血浆可溶性髓样细胞触发受体-1(sTREM-1)在脓毒症临床监测中的意义。方法:选择脓毒症患者32例为患者组,根据28d预后情况分为生存组(n=21)和死亡组(n=11)。以同期健康体检者25例为对照组。患者组入院24h内检测血常规,测定血清C反应蛋白(CRP),留取血浆,计算急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分;酶联免疫吸附法(ELISA)检测sTREM-1水平;比较患者组与对照组、生存组与死亡组间sTREM-1、CRP等情况。结果:患者组STREM-1、CRP、白细胞计数(WBC)和中性粒细胞比例(N)均高于对照组,差异有统计学意义(P<0.05或P<0.01)。死亡组的血浆sTREM-1水平和APACHEⅡ评分均高于生存组(P<0.05或P<0.01),2组间CRP、WBC、N及体温(T)差异无统计学意义(P>0.05)。患者组血浆sTREM-1水平与APACHEⅡ评分呈正相关(rs=0.426,P=0.032)。结论:血浆sTREM-1水平是脓毒症临床监测的重要指标,患者早期sTREM-1水平升高与不良预后相关。Objective：To investigate the clinical significance of soluble triggering receptor expressed on myeloid cells（sTREM）-1 in patients with sepsis.Methods：Using prospective,randomly control study design,32 patients suffered from sepsis were collected and divided into survival group（n=21） and non-survival group（n=11） according to 28-day prognosis.Twenty-five health volunteers were controls.Clinical date,including routine blood test and C-reactive protein（CRP）,were determined and APACHEⅡ score were recorded in 24 hours.The level of sTREM-1 was measured by enzyme linked immunoabsorbant assay（ELISA） and the differences were compared between groups.Results：The levels of sTREM-1,CRP,white blood cell（WBC） and neutrophil count percentage（N） were significantly higher in patients with sepsis than those of controls（P 0.05 or P 0.01）.The plasma levels of sTREM-1 and APACHEⅡ score were significantly higher in non-survival group（n=11） than those of survival group（n=21,P 0.05 or P 0.01）.There were no significant differences in CRP,WBC and neutrophil count percentage（N） and body temperature between non-survival group and survival group（P 0.05）.The level of sTREM-1 showed obviously positive correlation with APACHEⅡ score in patient group（rs = 0.426,P = 0.032）.Conclusion：Plasma level of sTREM-1 is an useful index for clinical monitoring in sepsis.The increased sTREM-1 was associated with the poor prognosis.

关 键 词：脓毒症 可溶性髓样细胞触发受体-1 预后 酶联免疫吸附测定 C反应蛋白质 白细胞 

分 类 号：R572[医药卫生—消化系统]