邻近山羊门静脉行高强度聚焦超声消融的病理观察  

Pathological Observation after MRI Guided High Intensity Focused Ultrasound Therapy for Ablating the Liver Tissues Adjacent to Goat Portal Vein

作　　者：江丰[1] 何敏[1] 刘映江[1] 黄秀[1] 张炼[1] 白晋[1] 王智彪[1] 

机构地区：[1]重庆医科大学生物医学工程系医学超声研究所,重庆400016

出　　处：《生物医学工程学杂志》2011年第4期666-669,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金重点项目资助(30830040)

摘　　要：观察使用磁共振（MRI）导航的高强度聚焦超声（MRgHIFU）消融靠近山羊门静脉的肝组织的病理变化;在MRI监控下,对50只山羊靠近门静脉0、5和10 mm处的肝组织进行热消融。其中40只山羊术后立即处死,另外10只在消融7 d后处死。病理观察显示靶区肝组织完全坏死,治疗后即刻0 mm组门静脉出现胶原纤维肿胀（CS）27/40（67.5%）例,血管壁断裂（VWF）为7/40（17.5%）例;5 mm组门静脉CS为8/40（20%）例,VWF（0/40,0%）,两组间CS和VWF发生率差异有显著性（P〈0.05）;10 mm组未见CS（0/40,0%）和VWF（0/40,0%）。消融后7d,各组门静脉标本在光镜下均未见CS和VWF。以上结果表明,MRgHIFU在距山羊门静脉0~5 mm处消融肝组织可能会造成门静脉的急性损伤,但这种损伤是可逆的。The present study was aimed to investigate the pathological changes after magnetic resonance imaging（MRI） guided high intensity focused ultrasound（MRgHIFU） therapy for ablating the liver tissue adjacent to goat portal vein.Fifty goats were involved in this study.Normal liver tissues at 0,5,and 10 mm distance from portal vein,respectively,were ablated with MRgHIFU.Among the 50 tested subjects,40 goats were sacrificed immediately after the operations,and the other 10 were sacrificed 7 days after the procedure for pathological examination of the targeted areas and the contiguous portal veins.Coagulation necrosis was observed in all the treated liver tissues.Collagen swelling（CS） and vessel wall fracture（VWF） emerged more frequently in the 0mm group than that in the 5mm group： CS [0mm group VS 5mm group=27/40（67.5%） VS 7/40（17.5%）,P0.05],VWF [0mm group VS 5mm group=8/40（20%）VS 0/40（0%）,P0.05]. Seven days after ablation,no portal vein damages（CS and VWF） were observed under light microscope.The results indicated that MRgHIFU could be used to ablate the liver tissue adjacent to goat portal vein effectively,which may cause blood vessel damage when the focus is on the wall of blood vessels（0 mm）.However,the pathological results indicated that these damages are reversible.

关 键 词：高强度聚焦超声 门静脉 病理观察 

分 类 号：R735.7[医药卫生—肿瘤]