老年帕金森病患者血尿酸水平及其与认知功能的关系  

Study on serum level of uric acid and on its relation with cognition function in elderly patients with Parkinson＇s disease

作　　者：刘涛[1] 陈峰[2] 文国强[1] 欧阳锋[1] 龙志刚[1] 李天炼[1] 陈涛[1] 

机构地区：[1]海南省人民医院神经内科,海口570311 [2]海南省人民医院放射科,海口570311

出　　处：《中华老年医学杂志》2011年第8期629-631,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨老年帕金森病（PD）患者血尿酸水平与认知功能的关系，并对相关因素进行分析。方法回顾性分析60例老年PD患者的病历资料，选择性别、年龄相匹配的60例健康体检者作为对照，记录性别、年龄、病程、Hoehn＆Yahr分期（H—Y分期）、尿酸、简易智能量表（MMSE）评分，并进行比较和相关性分析。结果老年PD组血浆尿酸水平[（262±53）umol／L]明显低于对照组[（332±45）umol／L]，差异有统计学意义（t=-6．724，P〈0．001）。PD组男性血浆尿酸水平[（271±48）〉mol／L]均值略高于女性水平[（254±39）umol／L]，但差异无统计学意义（t=3．282，P=0．058）。PD组男性血浆尿酸水平明显低于对照组男性尿酸水平[（353±62）umol／L]，差异有统计学意义（t=-5．625，P〈0．001）。PD组女性血浆尿酸水平低于对照组女性尿酸水平[（294±59）〉mol／L]，差异有统计学意义（t=-4．721，P=0．012）。老年PD各亚组间血尿酸水平无显著差异，但与对照组比较差异均有统计学意义（F=22，039，P〈0.01）。老年PD组血尿酸水平与病程长短无明显相关性（r=0．961，P〉0.05）。老年PD患者存在认知功能障碍，其MMSE评分与H—Y分期（r=-0．577，P=0．019）、年龄（r=-0．333，P=0．034）呈负相关，与血尿酸水平呈正相关（r=0．789，P=0．000），与病程（r=-0．333，P=0．027）、体质指数（BMI）（t=-0．410，P=0．115）无相关性。结论老年PD患者血尿酸水平降低，低尿酸水平可能与老年PD患者的认知功能障碍有关。Objective To explore the relationship between uric acid （UA） level and cognitive function in elderly patients with Parkinson, s disease （PD） and analyze the cognition related factors. Methods The clinical data of 60 elderly PD cases in our hospital from 2001 to 2009 were retrospectively analyzed. The 60 healthy people receiving medical examination in our hospital and matched by gender and age, were as control group. The information including gender, age, illness duration, Hoehn ＆ Yahr stage （H Y stage）, serum UA level and Mini-Mental State Examination （MMSE） scale were recorded. Results The serum UA level was significantly lower in PD group than in control group [（262±53） umol/L vs. （332±45） umol/L, t=6. 724, P〈0.001]. In PD group, the serum UA level was slightly higher in males than in females [（271 ±48） umol/L vs. （254±39）umol/L, t=3.282, P=0.058]. The serum UA level was significantly lower in male PD patients than in male controls [（353±62） umol/L, t=-5. 625, P〈0. 001], and was lower in female PD patients than in female controls [（294±59） umol/L, t=4.721, P=0.012]. There were no significant differences in serum UA level among different H Y stage subgroups （P〉0.05）, but the serum UA level was lower in different H-Y stage subgroups than in control group （F=22. 039, P〈 0.01 ）. There was no correlation between the UA level and the illness duration （r=0. 961, P〉0.05）. The MMSE score had significant difference between elderly PD group and control group （t= -3. 168, P〈0.001）. In PD patients, the MMSE score was positively correlated with serum UA level （r=0. 789, P=0. 000）, and was negatively correlated with H-Y stage （r= -0. 577, P=0. 019）, age （r=-0. 333, P=0. 034）, but was not correlated with illness duration （r=-0. 333, P=0. 207） and BMI （t =-0. 410, P=0. 115）. Conclusions The level of serum UA is lower in elderly patients with PD than in normal controls. There is correlation between the serum UA level and cognitive im

关 键 词：帕金森病 尿酸 认知功能障碍 相关因素 

分 类 号：R742.5[医药卫生—神经病学与精神病学]