高脂血症和视网膜色素上皮层-Bruch膜-脉络膜毛细血管复合体的相关性研究进展  

Associations between hyperlipemia and retinal pigment epithelium-Bruch membrane-choroid complex

作　　者：贾之祥[1] 刘广峰[1] 王禄娅 汪军[1] 

机构地区：[1]首都医科大学附属北京安贞医院,北京市100029

出　　处：《眼科新进展》2011年第8期789-792,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:30771986)~~

摘　　要：高脂血症和许多眼底临床疾病相关,它是引起眼科疾病的一个危险因素,国内外学者对此进行了多方面的研究。近年来研究发现,血脂异常可以导致视网膜色素上皮细胞的形态损害、Bruch膜脂质的沉着且破坏其完整性和导致脉络膜毛细血管内皮细胞的病理改变。本文就高脂血症对视网膜色素上皮层-Bruch膜-脉络膜毛细血管复合体的影响及其机制的研究进展进行综述,为预防和治疗相关眼科疾病提供思路。Hyperlipemia is a major risk factor of many ocular disorders,it closed related to many ocular fundus diseases,and there have been many studies about the associations between hyperlipemia and retinal pigment epithelium-Bruch membrane-choroid complex.The researchers found that hyperlipimia can induce morphological changes of retinal pigment epithelial cells,particles deposition in Bruch membrane and integrity breakup,and induce the damage of the endothelial cells of choroid blood vessel.This article reviews the recent advances in hyperlipemia on retinal pigment epithelium-Bruch membrane-choroid complex and provides insight into this kind of disease.

关 键 词：高脂血症 视网膜色素上皮 BRUCH膜 年龄相关性黄斑变性 

分 类 号：R774.5[医药卫生—眼科]