幽门螺杆菌口腔定植和胃肠疾病的关联性研究  

The correlation between oral colonization of Helicobacter pylori and gastrointestinal disease

作　　者：陈骏[1] 何祥一[1] 吴凌莉[1] 车团结[2] 

机构地区：[1]兰州大学口腔医学院口腔修复教研室 [2]兰州大学生命科学院细胞生物学研究所,兰州730000

出　　处：《华西口腔医学杂志》2011年第4期351-354,共4页West China Journal of Stomatology

基　　金：中央高校基本科研业务费专项基金资助项目(lzujbky-20-10-142)

摘　　要：目的分析口腔中幽门螺杆菌(H.pylori)的定植与胃肠疾病的关联性。方法采用细菌培养法,对173名胃肠疾病患者的唾液标本进行H.pylori检测,同时根据年龄、性别、胃肠疾病类型和牙周状况分组,分析不同组别H.pylori检测结果的差异性。结果胃肠疾病患者口腔唾液中H.pylori阳性率为40.46%。其中,男性高于女性(P<0.05);45～64岁年龄组H.pylori阳性率为56.72%,明显高于2个低年龄组(P<0.05);萎缩性胃炎组H.pylori阳性率为77.78%,与消化性溃疡组和浅表性胃炎组相比差异有统计学意义(P<0.05);牙周健康组和牙周袋组的H.pylori阳性率分别为15.38%、72.73%,差异有统计学意义(P<0.05)。结论 H.pylori在口腔中是一种条件致病菌,口腔中H.pylori检出率与牙周疾病的严重程度呈正相关,胃肠疾病患者口腔中H.pylori检出率与胃肠疾病的类型密切相关,不良牙周健康状况可能是胃肠疾病发生及复发的重要因素之一。Objective To investigate the correlation between Helicobacter pylori（H.pylori） colonization in the oral cavity and gastrointestinal disease.Methods 173 patients with gastrointestinal disease were grouped according to age,gender,periodontal status and types of gastrointestinal disease.H.pylori were detected from saliva samples of all patients by in vitro cultur.The H.pylori-positive rates in different groups were statistically analysed.Results The H.pylori-posi-tive rate in all patients was 40.46% and the difference between male and female showed significant（P0.05）.The H.pylori-positive rate was 56.72% in the age range 45-64,which was significantly higher than two younger age groups（P0.05）.The H.pylori-positive rate in patients with atrophic gastritis was 77.78%,of which the difference was signifi-cantly higher than superficial gastritis group and gastric and duodenal ulcer group respectively（P0.05）.The H.pyloripositive rate in healthy periodontia group was 15.38%,while that in periodontitis group was 72.73%（P0.05）.Conclusion H.pylori is a conditional pathogen.The H.pylori-positive rate from saliva is closely related to the types of gastrointestinal disease in patients,and it is correlated with the periodontal diseases as well.These findings suggest that the oral cavity with periodontal diseases is an ecological niche of H.pylori which might be an important cause for occur-rence and re-occurrence of gastrointestinal disease.

关 键 词：幽门螺杆菌 牙周状况 唾液 胃肠疾病 

分 类 号：R57[医药卫生—消化系统]