脑膜瘤继发癫癎的危险因素  

Risk factors for epilepsy secondary to meningioma

作　　者：吕健[1] 宋千[1] 周乐[1] 王睿智[1] 

机构地区：[1]西安交通大学医学院第二附属医院神经外科,710004

出　　处：《中国微侵袭神经外科杂志》2011年第8期343-347,共5页Chinese Journal of Minimally Invasive Neurosurgery

摘　　要：目的分析脑膜瘤继发癫癎的危险因素。方法回顾性分析102例脑膜瘤病人的临床资料,采用二分类Logistic回归分析方法分析肿瘤的位置、直径、数目、质地、水肿、硬脑膜尾征、出血、肿瘤钙化、囊变、瘤-脑界限、累及动脉、累及静脉窦、相邻颅骨改变、合并脑积水、合并颅内其他影像学改变、是否复发以及病人的年龄、性别、病程、运动障碍、感觉障碍、精神异常、视觉障碍、语言障碍、脑神经功能障碍、锥体束征、高血压、贫血、高血糖、心电图异常等30项客观指标与继发癫癎的相关程度。结果入院时有明确癫癎发作史34例(33.33%)。Logistic分析显示:肿瘤位置、瘤周水肿、肿瘤钙化等3项指标的优势比分别为16.189、2.775、31.597(均P<0.05)。结论肿瘤邻近大脑半球皮质、瘤周水肿、肿瘤钙化是脑膜瘤继发癫癎的独立危险因素。Objective To analyze the risk factors of epilepsy secondary to meningioma.Methods The clinical data of 102 patients with meningioma were analyzed retrospectively.The relationships between epilepsy secondary to meningioma and the objective indicators（tumor site,diameter,number,character,edema,dural tail sign,bleeding,calcification,cystic change,tumor-brain interface,involving artery,involving venous sinus,adjacent skull change,hydrocephalus,other intracranial imaging disorder,recurrence,age,sex,course of disease,dyspraxia,sensory disorder,mental disorder,visual disorder,aphasia,cranial nerve disorder,pyramidal sign,hypertension,anemia,hyperglycemia and ECG disorder） were analyzed with binary Logistic regression respectively.Results There were 34 patients（33.33%） with history of seizures at admission.The Logistic regression analysis showed that the dominance ratio of tumor site,peritumoral edema and tumor calcification were 16.189,2.775,31.597（all P0.05）.Conclusions Tumor adjacent to cortex of cerebral hemisphere,peritumoral edema and tumor calcification were independent risk factors of epilepsy secondary to meningioma.

关 键 词：脑膜瘤 癫癎 危险因素 

分 类 号：R739.45[医药卫生—肿瘤]