血浆白细胞介素6和10水平与不同类型淋巴瘤的关系及其临床意义  

Plasma interleukin-6 and interleukin-10 levels in different subtypes of lymphoma and their clinical significance

作　　者：王欣[1] 赵化荣[2] 顾霞[1] 刘攀[2] 哈德提.别克米托夫 

机构地区：[1]新疆医科大学第一附属医院病理科,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院肿瘤中心,新疆乌鲁木齐830054

出　　处：《南方医科大学学报》2011年第8期1360-1364,共5页Journal of Southern Medical University

基　　金：国家自然科学基金(30860096)~~

摘　　要：目的探讨不同类型淋巴瘤血浆白细胞介素6(IL-6)和10(IL-10)的表达以及与临床特征、治疗反应、预后指标的关系。方法采用酶联免疫吸附(ELISA)法测定132例恶性淋巴瘤患者及132例健康对照者血浆IL-6和IL-10浓度。结果不同类型淋巴瘤患者血浆IL-6和IL-10水平均高于健康对照组(P<0.05),不同类型比较除T-NHL组血浆IL-6水平高于B-NHL,差异有统计学意义(P<0.05),其余组间差异皆无统计学意义(P>0.05)。哈萨克族患者IL-6水平高于汉族和维吾尔族;有B症状、IPI高危组、β2-MG、LDH和CRP高水平组血浆IL-6水平高于无B症状、低危组、β2-MG、LDH和CRP低水A平r组bo,r差分异期有Ⅰ统～Ⅱ计、学无意B义症(状P、<β02.-0M5)G。和ACnnR APr低bo水r分平期组Ⅲ,差～Ⅳ异、有有统B计症学状意、β义2-(MPG<和0.0C5)R。P高化水疗平后(C组R)患血者浆IILL--61和0水IL平-1高0水于平An明n显低于PR、PD和未治疗组(P<0.05);血浆IL-10和IL-6及IL-10和β2-MG呈正相关(P<0.05)。结论淋巴瘤患者IL-6和IL-10水平明显高于健康对照组,其水平的高低与肿瘤负荷有关;检测血浆中IL-6和IL-10的水平,可以做为临床淋巴瘤诊断、判断疗效和预后的辅助指标。Objective To study the plasma levels of interleukin6（IL-6） and interleukin10（IL-10） in patients with lymphoma and their association with the clinical characteristics and prognosis.Methods The plasma levels of IL-6 and IL-10 were measured in 132 lymphoma patients and 132 healthy controls using enzyme-linked immunosorbent assay（ELISA）.Results The levels of plasma IL-6 and IL-10 in lymphoma patients were significantly higher than those in healthy controls（P0.05）.The plasm a levels of IL-6 were significant higher in T non-Hodgkin＇s lymphoma（T-NHL） patients than in B non-Hodgkin＇s lymphoma（B-NHL） patients（P0.05）,and were similar between other groups of different subtypes of lymphoma（P0.05）.Patients of Kazak nationality had a significantly higher plasma IL-6 level than those of Han and Uygur nationalities（P0.05）.The presence of B symptoms,a high risk defined by the International Prognostic Index（IPI）,high levels of plasma β2-MG,and elevated LDH and C-reactive protein（CRP） levels were all associated with a significantly increased plasma IL-6 level（P0.05）,and patients with Ann Arbor stage III-IV disease,B symptoms,and high plasma β2-MG and CRP levels had significantly higher IL-10 levels（P0.05）.The plasma IL-6 and IL-10 levels were significantly lower in patients with complete remission than in those with partial remission and progressive disease and than in those without treament（P0.05）.Plasma IL-10 was positively correlated to IL-6 and β2-MG levels（P0.05）.Conclusion Lymphoma patients have significantly increased plasma IL-6 and IL-10 levels with correlation to the tumor load.Plasma levels of IL-6 and IL-10 may serve as useful indicators for predicting the response to therapy and prognosis of lymphoma.

关 键 词：白细胞介素6 白细胞介素10 淋巴瘤 酶联免疫吸附法 

分 类 号：R733.1[医药卫生—肿瘤]