围着床期子宫内膜微血管密度评价子宫内膜容受性  

Endometrial microvessel density for assessing endometrial receptivity during the peri-implantation period

作　　者：李秋华[1] 余敏[1] 陈雷宁[1] 李红[1] 罗琛[1] 陈思梅[1] 全松[1] 

机构地区：[1]南方医科大学南方医院妇产科生殖医学中心,广东广州510515

出　　处：《南方医科大学学报》2011年第8期1365-1368,共4页Journal of Southern Medical University

基　　金：广东省自然科学基金(06024388;9151051501000066)

摘　　要：目的探讨围着床期子宫内膜微血管密度(MVD)评价子宫内膜容受性的价值。方法选择行体外受精-胚胎移植(IVF-ET)治疗的患者104例,在IVF-ET前1自然周期排卵后7 d用一次性宫腔组织吸引管获取子宫内膜组织,进行扫描电镜观察子宫内膜上皮胞饮突及MVD测定。追踪助孕结局分为临床妊娠组(50例)和未妊娠组(54例)。结果随机抽取临床妊娠组(4例)和未妊娠组(4例)共8例患者的子宫内膜组织行扫描电镜检查,均观察到胞饮突,证实所取的子宫内膜组织均在围着床期。临床妊娠组MVD[(4.12±1.84)%]高于未妊娠组MVD[(3.46±1.26)%],差异有统计学意义(t=-2.127,P=0.036),但MVD预测妊娠的ROC曲线下面积仅为0.598,用于判断妊娠特异性不高。结论在辅助生殖技术中测量子宫内膜MVD评价子宫子宫内膜容受性有一定意义,但是特异性欠佳。Objective To evaluate the value of endometrial microvessel density（MVD） in assessing the endometrial receptivity during the peri-implantation period.Methods A total of 104 patients undergoing in vitro fertilization and embryo transfer（IVF-ET） treatment were analyzed retrospectively.The subjects were divided into clinical pregnancy group（50 cases） and nonpregnant group（54 cases） according to the IVF-ET outcome.Endometrial tissues were collected 7 days after the natural ovulation prior to IVF-ET for measurement of the endometrial MVD using electron microscopy,which was analyzed in relation to the clinical outcome of the treatment.Results The endometrial MVD was significantly higher in the clinical pregnancy group than in the nonpregnant group（4.12±1.84）% vs（3.46±1.26）%,t=-2.127,P=0.036）.ROC curve analysis showed that the MVD had an area under the curve slightly over 0.5（0.598） for predicting clinical pregnancy,suggesting a poor specificity in predicting the clinical outcome of the treatment.Conclusion In IVF-ET cycles,the endometrial MVD during the peri-implantation period is helpful for assessing the endometrial receptivity,but the specificity remains low.

关 键 词：子宫内膜容受性 微血管密度 胞饮突 扫描电镜 体外受精-胚胎移植 

分 类 号：R714.8[医药卫生—妇产科学]