单纯放疗和手术结合放疗治疗中耳癌的Meta分析  

Meta-analysis of the effects of radiotherapy and surgery on carcinoma of the middle ear

作　　者：蔡青[1] 肖伯奎[1] 陶泽璋[1] 华清泉[1] 

机构地区：[1]武汉大学人民医院耳鼻咽喉-头颈外科,武汉430060

出　　处：《临床耳鼻咽喉头颈外科杂志》2011年第16期741-743,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:用Meta分析方法评估中耳癌手术切除结合放疗和单纯放疗对患者生存率的影响。方法:查询筛选合格病例对照研究文献5篇,Meta分析采用Review Manager5.0统计软件,对文献结果进行定量综合分析。结果:5项中耳癌手术结合放疗和单纯放疗对中耳癌患者生存率影响的对照研究具有同质性,可以合并结果;合并效应量的检验z=0.29,P>0.05,合并效应量OR采用固定效应模型。OR合并值为0.91[95%(0.49～1.70)],菱形分布在垂直线的两侧。结论:单纯放疗和手术结合放疗对于中耳癌治疗的生存率差别并不大。我们认为早期中耳癌的治疗应以单纯放疗为首选。Objective：To evaluate the effects of radiotherapy and surgery on carcinoma of the middle ear.Method：A review of five published literatures was conducted according to defined selection criteria by the Review Manager 5.0 statistical software.Result：There were no systematic reviews or large-scale RCTs between radiotherapy and symptomatic treatment containing surgery and radiotherapy for carcinoma of the middle ear.Conclusion：Radiotherapy and symptomatic treatment for carcinoma of the middle ear have no obvious differences.The radiotherapy is the first choice for the treatment of squamous cell carcinoma of the middle ear.

关 键 词：耳肿瘤 放射治疗 手术治疗 META分析 

分 类 号：R739.61[医药卫生—肿瘤]