Na2SeO3对小鼠巨噬细胞功能的影响  

The effect of Na2SeO3 on the function of mice macrophage

作　　者：李咏梅[1] 卢澍勤[1] 邵世和[1] 陈曦[1] 赵德生 

机构地区：[1]吉林医学院微生物教研室,吉林 132001 [2]吉林市儿童医院

出　　处：《吉林医学院学报》1999年第3期5-6,共2页

基　　金：吉林市科委计划项目

摘　　要：目的：试验Ｎａ２ＳｅＯ３对小鼠巨噬细胞功能的影响。方法：将Ｎａ２ＳｅＯ３按１ｕｇ／ｇ的量以腹腔注射和灌胃方式给入小鼠。２０ｄ后做巨噬细胞功能测定试验。结果：Ｎａ２ＳｅＯ３腹腔注射组和灌胃组小鼠的巨噬细胞蚕噬百分比，吞噬指数均高于正常对照组Ｐ〈０．０５。结论：Ｎａ２ＳｅＯ３有提高小鼠巨噬细胞蚕噬功能的作用。提示硒可能通过增强吞噬细胞功能而达到抗肿瘤作用。Objections:To test the effect of Na_2SeO_3 on the funciton of mice Macrophage.Methods:Na_2SeO_3(1ug/g) to mice by injection and oral administration After 20ds,the funciton of macrophage were tested.Results:The phagocytic percentage and index of mice macrophages in Na_2SeO_3 injection group and oral administration group were higher than that of the control (P<0.05).Conclusion:Na_2SeO_3 has the effect of improving phagocytosis of mice macrophage.It suggests that Selenium has the effect of antitumor by increasing the phagocytic function of macrophages.

关 键 词：Na2SeO3 巨噬细胞 肿瘤 免疫疗法 

分 类 号：R730.51[医药卫生—肿瘤]