首发精神分裂症患者利培酮治疗前后血浆IL-2、IL-6变化的研究  

The study of level changes of serum Interleukin-2、Interleukin-6 in patients with first Schizophrenia at pre and post treatment of Risperidone

作　　者：冀德才[1] 于彩霞[1] 孟庆霞[1] 党亚军 

机构地区：[1]吉林市精神病医院,吉林吉林132011

出　　处：《中国医学工程》2011年第6期58-59,共2页China Medical Engineering

摘　　要：目的研究首发精神分裂症患者血浆中白细胞介素2(IL-2)、白细胞介素6(IL-6)的变化。方法对首发精神分裂症患者36例,单独应用利培酮治疗;30例健康志愿者为对照组。采用酶联免疫吸附法测定血浆中IL-2、IL-6的浓度,并进行组间比较。结果精神分裂症组在治疗前血浆IL-2、IL-6的水平显著增高,治疗8周症状缓解后血浆IL-2、IL-6的水平下降;症状基本缓解后与治疗前比较差异有显著性(p<0.05)。结论精神分裂症患者存在免疫功能紊乱。【Objective】 To evaluate the changes of interleukin-2 and interleukin-6 plasma levels of first episode paranoid scgizophrenics.【Methods】 36 inpatients with first episode paranoid schizophrenia were collected as case group and treated with Risperidone.We obtained plasma when schizophrenic patients were both on admissionand in astate of initial remission 8 weeks after admission.30 healthy volunteers were enrolled as control group.The contents of IL-2 and IL-6 were measured with enzyme linked immunosorbent assay（ELISA）.The parameters were performed by statistics analysis.【Results】 Results On admission the levels of IL-2 and IL-6 plasma were significantly higher in schizophrenic patients in comparison to control group.Eight weeks after admission The levels of IL-2 and IL-6 plasma were significantly higher in comparison to control group.When initial remission compared with acute disease pronounced difference was observed for the levels of IL-2 and IL-6 inplasma.【Conclusion】 Schizophrenic patients had immune dysfunction.

关 键 词：精神分裂症 白细胞介素2 白细胞介素6 利培酮 

分 类 号：R749.3[医药卫生—神经病学与精神病学]