鸦胆子油乳注射液联合DP方案治疗中晚期非小细胞肺癌的临床观察  

Clinical observation of brucea javanica oil emulsion combined with DP chemotherapy in treating advanced non-small-cell lung cancer

作　　者：牛海玉[1] 吴昌平[1] 蒋敬庭[1] 徐斌[1] 赵洁敏[1] 周文杰[1] 石红兵[1] 王琦[1] 胡文蔚[1] 

机构地区：[1]苏州大学附属第三医院肿瘤科,江苏常州213003

出　　处：《中国医师进修杂志》2011年第22期13-16,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的观察鸦胆子油乳注射液联合DP方案治疗中晚期非小细胞肺癌的临床疗效及不良反应。方法将48例中晚期非小细胞肺癌患者按机械抽样法随机分为治疗组和对照组，每组24例。治疗组采用鸦胆子油乳注射液联合DP方案化疗，对照组采用DP方案化疗。连用2个周期后评价疗效。结果治疗组和对照组近期有效率分别为54．2％（13／24）和45．8％（11／24），两组比较差异无统计学意义（x2=0．333，P=0．564）。生活质量提高加稳定率治疗组为87．5％（21／24），对照组为58．3％（14／24），两组比较差异有统计学意义（x2=5．169，P=0．023）。体重增加及稳定率治疗组为79．2％（19／24），对照组为45．8％（11／24），两组比较差异有统计学意义（x2=5．689，P=0．017）。治疗组恶心、呕吐发生率为45．8％（11／24），对照组为41．7％（10／24），两组比较差异无统计学意义（r=0．085，P=0．771）。治疗组外周血白细胞下降程度减轻，恢复快，化疗后免疫功能好于对照组。结论鸦胆子油乳注射液联合DP方案治疗中晚期非小细胞肺癌，可以提高患者的细胞免疫功能、改善患者的生活质量，减轻化疗的不良反应。Objective To evaluate the clinical efficacy and adverse effects of brucea javanica oil emulsion combined with DP chemotherapy in treating advanced non-small-cell lung cancer. Methods Totally 48 patients with advanced non-small-cell lung cancer were divided into two groups randomly by mechanical sampling method. Twenty-four cases in treatment group were treated by brucea javanica oil emulsion combined with DP chemotherapy, while 24 cases in control group were treated by DP chemotherapy only. The clinical effects were evaluated after treatment of two cycles. Results The short-term effective rate was 54.2% （13/24） in treatment group and 45.8% （11/24） in control group, and there was no significant difference between two groups （X2 = 0.333, P = 0.564）. The rate of increased and stable life quality was 87.5%（21/24） in treatment group and 58.3%（14/24） in control group,and there was significant difference between two groups （ X2 = 5.169, P = 0.023 ）.The rate of increased and stable weight was 79.2% （ 19/24 ） in treatment group and 45.8%（ 11/24 ） in control group, and there was significant difference between two groups （X2 = 5.689,P = 0.017 ）. The incidence of nausea or vomiting was 45.8% （11/24） in treatment group and 41.7%（ 10/24 ） in control group, and there was no significant difference between two groups （ X2 = 0.085, P = 0.771）. Compared with those in control group, patients in treatment group had less adverse effects in decreasing of peripheral blood leucocytes and showed better immune function. Conclusion Brucea javanica oil emulsion combined with DP chemotherapy in treating advanced non-small-cell lung cancer has good clinical effect, especially enhances the quality of life, improves immune function and decreases the adverse effects of chemotherapy.

关 键 词：癌 非小细胞肺 鸦胆子 抗肿瘤联合化疗方案 

分 类 号：R734.2[医药卫生—肿瘤]