脑梗死患者血清超敏C反应蛋白的改变及其临床意义  

Clinical significance and change of serum high-sensitivity C-reactive protein in cerebral infarction patients

作　　者：李建川[1] 李国梅[1] 孙润海[1] 

机构地区：[1]山东省淄博市临淄区人民医院神经内科,255400

出　　处：《中国医师进修杂志》2011年第22期33-34,共2页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨脑梗死患者血清超敏C反应蛋白（hs-CRP）水平的变化及其与脑梗死病情和预后的关系。方法选择97例脑梗死患者（观察组）和72例健康体检者（对照组），采用酶联免疫吸附测定（EusA）法测定观察组不同时期hs—CRP水平，分析其与脑梗死病情轻重及临床神经功能缺损程度评分的相关性，并与对照组进行比较。结果观察组入院第24天hs-CRP水平[（3．9±1．8）mg／L]较第1、4、8天hs．CRP水平[（5．8±1．9）、（6．4±2．4）、（5．7±2．0）mg／L]显著下降．差异有统计学意义（P〈0．05）；观察组血清hs—CRP水平与神经功能缺损程度评分呈正相关（r=0．214，P〈0．01）。结论血清hs-CRP水平与脑梗死的发生具有密切的关系，是评价脑梗死严重程度和预后的一个重要的生物学指标，对脑梗死的预测和干预处理有一定的临床价值。Objective To investigate the changes of serum high-sensitivity C-reactive protein （hs-CRP） in cerebral infarction patients and its relationship with the condition of cerebral infarction and prognosis. Methods Ninety-seven cases with cerebral infarction patients （observation group） and 72 healthy subjects （control group） were selected. The levels of hs-CRP at different periods were detected by enzyme-linked immunosorbent assay （ELISA） in observation group, and its relationship with the severity of cerebral infarction level degree and neurological deficit scores was analyzed and compared with control group. Results The levels of hs-CRP at the 24th day [ （3.9 ± 1.8） mg/L ] were lower than those at the 1,4,8th day [ （5.8 ±1.9）, （6.4 ± 2.4）, （5.7 ± 2.0） mg/L] in observation group, and the difference was significant （P〈 0.05）. The levels of hs-CRP showed positive correlation with neurological deficit scores（r = 0.214,P〈 0.01 ）. Conclusions The levels of hs-CRP have close relationship with cerebral infarction, and it can be used as an important biological indicator in evaluating the severity and prognosis of cerebral infarction and has clinical value in prediction and intervention of cerebral infarction.

关 键 词：C反应蛋白质 脑梗塞 酶联免疫吸附测定 预后 

分 类 号：R74[医药卫生—神经病学与精神病学]