透明质酸钠对颞下颌关节骨关节病患者关节滑液中基质金属蛋白酶2、3的影响  

Effect of sodium hyaluronate on the level of matrix metalloproteinase-2 and matrix metalloproteinase-3 in synovial fluid of patient with temporamandibular joint osteoarthritis

作　　者：刘培才[1] 王东[1] 彭诚[1] 陈乐[1] 张媛[1] 

机构地区：[1]天津医科大学第二医院口腔颌面外科,300211

出　　处：《中华口腔医学研究杂志（电子版）》2011年第4期11-14,共4页Chinese Journal of Stomatological Research(Electronic Edition)

摘　　要：目的研究颞下颌关节(TMJ)上腔注射透明质酸钠(SH)治疗颞下颌关节骨关节病(TMJOA)前后关节滑液中基质金属蛋白酶2(MMP-2)和MMP-3含量的变化,探讨SH治疗TMJOA的机制。方法将30例TMJOA患者随机分成关节腔冲洗加SH治疗组和单纯关节腔冲洗组两组,6例志愿者为对照组。观察两种方法治疗前后关节滑液中MMP-2、3含量的变化。结果冲洗加SH组的临床疗效优于单纯关节腔冲洗组(开口度比较P<0.01,VAS比较P<0.05);无症状志愿者中1例检测出少量的MMP-2(31.12μg/L)和MMP-3(13.32μg/L);治疗后冲洗加SH组比单纯关节腔冲洗组MMP-2、3含量明显降低(P<0.01)。结论 SH可能通过降低TMJOA患者关节滑液中的MMP-2、3水平,减缓了关节软骨基质破坏速度,从而发挥对TMJOA的治疗作用。Objective To study the change of matrix metalloproteinase-2 （MMP-2） and matrix metalloproteinase-3 （MMP-3） level in temporamandibular joint （TMJ） synovial fluid after sodium hyaluronate （SH） irrigation in temporamandibular joint osteoarthritis （TMJOA） patients. Methods Thirty patients suffered from TMJOA were randomly devided into two groups, treated respectively with lavage and SH injection for the trail group and only lavage for the control group. The MMP-2 and MMP-3 level was examined before and after the treaments. Results The clinical effect of the trail group was better than that of the control group （the opening degree：P〈 0.01, VAS：P〈 0.05）; A small amount of MMP-2 （31.12 μg/L） and MMP-3 （13.32 μg/L） were detected in one case of asymptomatic volunteers; The change of MMP-2, 3 level in the trail group was higher than that in control group. Conclusion SH may slow the destruction of articular cartilage matrix by reducing the MMP-2, 3 level in TMJ SF in TMJOA patients, thus plays a role in the treatment of TMJOA.

关 键 词：颞下颌关节骨关节病 透明质酸钠 基质金属蛋白酶2 基质金属蛋白酶3 

分 类 号：R782.2[医药卫生—口腔医学]