宫颈鳞状细胞癌原发灶及淋巴结转移灶中ki67及E-cadherin的表达  

Expression of E-cadherin and Ki67 in Primary Uterine Cervical Squamous Cell Carcinoma and Lymph Node Metastases

作　　者：曾永群[1] 肖胜军[1] 张小玲[2] 李凡彩[1] 

机构地区：[1]桂林医学院附属医院,桂林市541000 [2]桂林医学院病理教研室,桂林市541000

出　　处：《广西医学》2011年第9期1106-1108,共3页Guangxi Medical Journal

基　　金：广西桂林市科学研究与技术开发计划项目(20090540)

摘　　要：目的检测宫颈鳞状细胞癌原发灶及淋巴结转移灶中细胞增殖标记ki67及上皮型黏附分子(E-cadherin)的表达差异,探讨两者在细胞增殖及迁移特性的差异。方法 60例有淋巴结转移的宫颈鳞状细胞癌,采用免疫组化检测ki67及E-cadherin在宫颈鳞状细胞癌原发灶及相应淋巴结转移灶中的表达差异。结果原发灶及淋巴结转移灶中ki67阳性表达率均为85.0%(51/60),两者密切相关(P<0.01)。E-cadherin在原发灶及淋巴结转移灶中的阳性表达率分别为56.67%(34/60)和63.33%(38/60);两者的表达差异有统计学意义(P<0.01)。结论宫颈鳞状细胞癌组织原发灶及淋巴结转移灶细胞增殖标记ki67高度一致,其细胞增殖能力没有异质性;而E-cadherin表达上调,提示淋巴结转移过程中在局部转移灶肿瘤细胞发生了间质-上皮转化。Objective To investigate the expressions of E-cadherin and ki67 in tissue of primary uterine cervical squamous cell carcinoma and lymph node metastases. Methods 60 cases of cervical squamous cell carcinoma and lymph node metastases were enrolled. Paraffin embedded tissue were assayed by immunohistochemistry for ki67 and E-cadherin. Results The positive expression of ki67 in both tissue were 85.00% （51/60）;ki67 expression in primary tumor was closely associated with that in metastases（ r = 0. 889 ,P 〈 0.001 ）. The positive expression of ki67 in primary cervical squamous cell carcinoma was 56.67% （34/60） and 63.33% （38/60） in lymphatic metastasis ; The expression score difference between primary tumor and metastasis showed significance （ P 〈 0.01 ）. Conclusion The ki67 expressions in primary uterine cervical squamous cell carcinoma and lymphatic metastases show high consistency,interfering that no heterogenecity in proliferation potent between them. E-cadherin upregulates in corresponding lymphatic metastases, signifying the tumor ceils undergoing mesenchymal-epithial transition in the process of lymphatic metastasis.

关 键 词：宫颈鳞状细胞癌 KI67 上皮型钙黏附分子 上皮-间质转化 间质-上皮转化 

分 类 号：R737.33[医药卫生—肿瘤]