立体定向囊液引流结合伽玛刀治疗囊性脑转移瘤  

Stereotactic drainage combined Gamma Knife radiosurgery treat cystic brain metastasis

作　　者：于新[1] 张剑宁[1] 孙君昭[1] 亓树彬[1] 王洪伟[1] 杜亚楠[1] 刘锐[1] 王亚明[1] 刘宗惠[1] 

机构地区：[1]海军总医院,北京100048

出　　处：《山东医药》2011年第28期20-22,共3页Shandong Medical Journal

摘　　要：目的探讨立体定向囊液引流结合伽玛刀在治疗囊性脑转移瘤中的作用。方法应用立体定向囊液引流结合伽玛刀治疗脑转移瘤患者79例,伽玛刀治疗的处方剂量为12～28 Gy(平均18.7 Gy)。结果囊液抽吸前肿瘤体积为4.5～72.3 ml(平均25.6 ml),抽吸或引流囊液3.5～45.4 ml(平均16.2 ml),抽吸后肿瘤体积为1.8～30.1 ml(平均12.3 ml),体积缩小率为15%～68%(平均52%),肿瘤局部控制率为93.1%,总生存期为16个月,1年和2年生存率分别为57.1%和32.1%。结论立体定向囊液引流结合伽玛刀治疗囊性转移瘤是可行的。Objective To investigate the feasibility and efficacy of stereotactic drainage combined Gamma Knife radiosurgery to treat cystic metastatic tumors.Methods 79 consecutive patients with cystic brain metastases underwent combination treatment of stereotactic drainage and Gamma Knife radiosurgery in our hospital.The mean prescription dose to the tumor margin was 18.7 Gy（range 12-28 Gy）.Results Before drainage the mean tumor volume was 25.6 ml（range 4.5-72.3 ml）;before Gamma Knife radiosurgery the mean tumor volume was 12.3 ml（range 1.8-30.1 ml）.The volume reduction was approximately 52%（range 15%-68%）.Local tumor control was achieved in 93.1% of the patients.Overall median patient survival was 16 months.The 1-and 2-year survival rate was 57.1% and 32.1%.Conclusion Stereotactic drainage combined Gamma Knife radiosurgery to treat the patients with cystic metastatic tumors is feasible.

关 键 词：脑肿瘤 立体定向囊液引流 伽玛刀 

分 类 号：R739.41[医药卫生—肿瘤]