亚甲基四氢叶酸还原酶基因C677T多态性与缺血性脑卒中关系的荟萃分析  

Relationship between methylenetetrahydrofolate reductase gene C677T polymorphism and susceptibility of ischemic stroke： a meta-analysis

作　　者：于慧会[1] 张文良[1] 时景璞[1] 

机构地区：[1]中国医科大学附属第一医院临床流行病教研室,沈阳110001

出　　处：《中华医学杂志》2011年第29期2060-2064,共5页National Medical Journal of China

摘　　要：目的综合评价亚甲基四氢叶酸还原酶（MTHFR）基因多态性与缺血性脑卒中（IS）在不同种族间的关系。方法电子检索MEDHNE、EMBASE、Cochrane Library等数据库，查找已发表的相关文献。采用荟萃分析方法，对17篇关于MTHFR基因多态性与缺血性脑卒中关系的研究文献进行综合定量分析。结果荟萃分析表明，携带MTHFR基因1Tr基因型发生缺血性脑卒中的危险性是非TT基因型的1．30倍，95％CI为1．11—1．52。携带MTHFR基因CC基因型发生缺血性脑卒中的危险性是非CC基因型的0．88倍，95％ CI为0．79～0．98。亚组分析显示MTHFR基因发生缺血性脑卒中的危险性因种族而异，高加索人群更易于发生缺血性脑卒中。结论MTHFR基因C677T多态性与高加索人缺血性脑卒中的易感性密切相关，与蒙古人及其他人种缺血性脑卒中的关系需进一步研究讨论。Objective To evaluate the relationship between the methylenetetrahydrofolate reductase （MTHFR） gene polymorphism and the susceptibility of ischemic stroke among different ethnic populations. Methods The databases of MEDLINE, EMBASE, Cochrane Library and others were searched. And a total of 17 studies published in English between 2000 and October 2010 on the association of MTHFR gene C677T polymorphism with ischemic stroke were selected. A comprehensive quantitative analysis was performed by recta-analysis. Results The results showed that the pooled OR values of ischemic stroke with TT and CC genotype were 1.30 （95% CI： 1.11 to 1.52） and 0. 88 （95% CI： 0. 79 to 0.98） respectively. And when sub-grouped by ethnic populations, the Caucasians were more likely than other populations to suffer ischemic stroke. There was a low probability of publication bias. Conclusion The presence of MTHFR TT gene is associated with an elevated risk of developing ischemic stroke, especially in Caucasians.

关 键 词：亚甲基四氢叶酸还原酶 脑梗死 荟萃分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]