氨基酸修饰环糊精对脂肪醇的分子识别研究  

STUDY ON MOLECULAR RECOGNITION OF ALIPHETIC ALCOHOLS BY AMINO ACID-MODIFIED CYCLODEXTRINS

作　　者：韩宝航[1] 刘育[1] 孙世新[1] 陈荣悌[1] 

机构地区：[1]南开大学化学系,天津300071

出　　处：《化学研究与应用》1999年第6期653-656,共4页Chemical Research and Application

基　　金：国家自然科学基金!资助项目 (2 96 72 0 2 1)

摘　　要：本文合成了 L-苯丙氨酸修饰 β-环糊精 (1 ) ,应用荧光光谱分光光度滴定方法测定了 2 5℃下 1与几种脂肪醇在磷酸缓冲溶液 (p H7.2 0 )中形成包结络合物的稳定常数 ,从主 -客体间的尺寸 /形状适合、客体分子的刚性及疏水性、疏水相互作用、范德华力等方面考察了主体对客体的分子识别 ,并与 L -色氨酸修饰β-环糊精的分子识别进行了比较。L Phenylalanine modified β cyclodextrin (1) has been synthesized and the stability constants for the complexation of 1 with several aliphatic alcohols determined through spectrofluorometric titration performed in aqueous phosphate buffer solution (pH 7.20) at 25℃. The molecular recognition of the aliphatic alcohol guests was discussed from the viewpoint of size/shape fit,the rigidity and hydrophobicity of guest molecules,as well as the hydrophobic interaction and van der Waals forces between the host and guest molecules.The molecular recognition behavior was also compared with that of L tryptophan modified β cyclodextrin.

关 键 词：化学修饰 环糊精 分子识别 脂肪醇 氨基酸 

分 类 号：O623.41[理学—有机化学] O636.12[理学—化学]